Aragona F, Franco V, Rodolico V, Dardanoni G, Cabibi D, Melloni D, Pavone C, Campesi G, Pavone-Macaluso M
Institute of Pathologic Anatomy, University of Palermo, Italy.
Urol Res. 1989;17(1):35-40. doi: 10.1007/BF00261048.
To distinguish prostatic dysplasia (or adenosis) from well differentiated adenocarcinoma on transrectal needle biopsy, a morphometric study was conducted on 20 cases of adenosis and 20 cases of well differentiated adenocarcinoma of the prostate. About 100 cells for each patient were analyzed by means of a computerized image analyzer, and mean nuclear diameter, mean nuclear area, mean form factor and number of cells in eight classes of nuclear diameter were studied. The best predictors of malignancy (evaluated by means of Receiver Operating Characteristics curves) were mean nuclear area greater than 28 mu2, presence of more than 5% of cells with nuclear diameter greater than 6.15 mu, and mean nuclear diameter greater than 5 mu. Using these diagnostic criteria the probability of malignancy for a positive specimen rises from 14% (pre-test) to 75% (post-test).
为了在经直肠穿刺活检中鉴别前列腺发育异常（或腺病）与高分化腺癌，对20例前列腺腺病和20例高分化腺癌进行了形态计量学研究。通过计算机图像分析仪对每位患者约100个细胞进行分析，研究了平均核直径、平均核面积、平均形态因子以及八类核直径的细胞数量。（通过受试者工作特征曲线评估）恶性肿瘤的最佳预测指标为平均核面积大于28μm²、核直径大于6.15μm的细胞占比超过5%以及平均核直径大于5μm。使用这些诊断标准，阳性标本的恶性肿瘤概率从14%（检测前）升至75%（检测后）。
