Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Center, University of Glasgow, Glasgow, Scotland, UK.
Division of Geriatrics & Nutritional Sciences, Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA.
Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):104-109. doi: 10.1097/MCO.0000000000000441.
Muscle mass and function decline progressively starting in middle age, which can result in sarcopenia and affect people's mobility and independence later in life. Exercise training and increased protein intake are typically recommended to counteract the age-associated decline in muscle mass and function. However, few people comply with exercise recommendations and the effectiveness of high-protein intake to halt the decline in muscle mass and function has not been proven. This review aims to explore recent developments in the potential for fish-oil derived n-3 polyunsaturated fatty acids (n-3 PUFA) to improve muscle mass and function in older people.
The results from several recent studies demonstrate that dietary supplementation with fish oil-derived n-3 PUFA stimulates muscle protein synthesis and improves muscle mass and function in sedentary older adults and augments the resistance exercise training-induced increase in muscle strength in older adults. The exact mechanisms by which fish oil-derived n-3 PUFAs exert their beneficial effects on muscle mass and function remain to be elucidated.
Fish-oil supplementation has antisarcopenic effects and should be considered in the clinical care of older adults.
肌肉质量和功能从中年开始逐渐下降，可导致肌肉减少症，并影响人们晚年的活动能力和独立性。通常建议进行运动训练和增加蛋白质摄入，以对抗与年龄相关的肌肉质量和功能下降。然而，很少有人遵守运动建议，并且高蛋白质摄入对阻止肌肉质量和功能下降的有效性尚未得到证实。本综述旨在探讨鱼油衍生的 n-3 多不饱和脂肪酸（n-3 PUFA）在改善老年人肌肉质量和功能方面的最新进展。
几项最近的研究结果表明，饮食补充鱼油衍生的 n-3 PUFA 可刺激肌肉蛋白质合成，改善久坐不动的老年人的肌肉质量和功能，并增强老年人抵抗运动训练引起的肌肉力量增加。鱼油衍生的 n-3 PUFAs 对肌肉质量和功能产生有益影响的确切机制仍有待阐明。
鱼油补充剂具有抗肌肉减少症的作用，应在老年人的临床护理中考虑。
