Thanh Nguyen Tan, Tuan Nguyen Ngoc, Kuo Ping-Chung, Dung Doan Manh, Phuong Doan Lan, Giang Dinh Thi Truong, Wu Tian-Shung, Thang Tran Dinh
a School of Chemistry, Biology and Environment , Vinh University , Vinh City , Vietnam.
b Institute of Biotechnology and Food Technology , Industrial University of Ho Chi Minh City , Ho Chi Minh City, Vietnam.
Nat Prod Res. 2018 Oct;32(20):2392-2397. doi: 10.1080/14786419.2017.1413572. Epub 2017 Dec 13.
A new tirucallane-type triterpenoid igniarine (1), and four known compounds meshimakobnol A (2), meshimakobnol B (3), ergosterol (4) and ergosterol peroxide (5), were purified from the methanol extracts of the fruiting bodies of Phellinus igniarius (DC. ex Fr.) Quél. The structure of 1 was elucidated using a combination of 1D and 2D NMR techniques and HR-ESI-MS analyses. In addition, the isolated compounds were examined for their cytotoxicity against several tumour cell lines and part of the tested compounds demonstrated weak cytotoxicity.
从桑黄（Phellinus igniarius (DC. ex Fr.) Quél.）子实体的甲醇提取物中纯化得到一种新的四环三萜类化合物igniarine（1）以及四种已知化合物meshimakobnol A（2）、meshimakobnol B（3）、麦角甾醇（4）和过氧化麦角甾醇（5）。通过一维和二维核磁共振技术以及高分辨率电喷雾电离质谱分析相结合的方法阐明了化合物1的结构。此外，对分离得到的化合物进行了针对几种肿瘤细胞系的细胞毒性检测，部分受试化合物表现出较弱的细胞毒性。
