Department of Radiology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Sci Rep. 2017 Dec 13;7(1):17502. doi: 10.1038/s41598-017-17753-9.
The purpose of this study is to test the feasibility of applying a dual-input two-compartment liver perfusion model to patients with different pathologies. A total of 7 healthy subjects and 11 patients with focal liver lesions, including 6 patients with metastatic adenocarcinoma and 5 with hepatocellular carcinoma (HCC), were examined. Liver perfusion values were measured from both focal liver lesions and cirrhotic tissues (from the 5 HCC patients). Compared to results from volunteer livers, significantly higher arterial fraction, fractional volume of the interstitial space, and lower permeability-surface area product were observed for metastatic lesions, and significantly higher arterial fraction and lower vascular transit time were observed for HCCs (P < 0.05). Significantly lower arterial fraction and higher vascular transit time, fractional volume of the vascular space, and fractional volume of the interstitial space were observed for metastases in comparison to HCCs (P < 0.05). For cirrhotic livers, a significantly lower total perfusion, lower fractional volume of the vascular space, higher fractional volume of the interstitial space, and lower permeability-surface area product were noted in comparison to volunteer livers (P < 0.05). Our findings support the possibility of using this model with 3D free-breathing acquisitions for lesion and diffuse liver disease characterization.
本研究旨在测试将双输入双室肝脏灌注模型应用于不同病理患者的可行性。共检查了 7 名健康受试者和 11 名局灶性肝病变患者，包括 6 名转移性腺癌患者和 5 名肝细胞癌（HCC）患者。从局灶性肝病变和肝硬化组织（来自 5 名 HCC 患者）测量了肝脏灌注值。与志愿者肝脏的结果相比，转移性病变的动脉分数、间质空间分体积明显较高，而渗透性表面积产物明显较低；HCC 的动脉分数明显较高，血管通过时间明显较低（P<0.05）。与 HCC 相比，转移瘤的动脉分数较低，血管通过时间较高，血管空间分体积较高，间质空间分体积较高（P<0.05）。与志愿者肝脏相比，肝硬化肝脏的总灌注量较低，血管空间分体积较低，间质空间分体积较高，渗透性表面积产物较低（P<0.05）。我们的研究结果支持使用这种模型与 3D 自由呼吸采集进行病变和弥漫性肝脏疾病特征描述的可能性。
