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口腔黏膜类天疱疮——两例临床表现各异的病例报告。

Oral mucous membrane pemphigoid - Two case reports with varied clinical presentation.

作者信息

Dharman Sreedevi, Muthukrishnan Arvind

机构信息

Department of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India.

出版信息

J Indian Soc Periodontol. 2016 Nov-Dec;20(6):630-634. doi: 10.4103/jisp.jisp_155_16.

DOI:10.4103/jisp.jisp_155_16
PMID:29238145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5713088/
Abstract

Mucous membrane pemphigoid (MMP) is a heterogeneous group of autoimmune chronic inflammatory, subepithelial blistering disorder, predominantly involving the mucous membranes. It has a female predilection and commonly occurring after the fifth decade of life. The oral mucosa is affected in more than 90% of cases. Dentists could be the first health personnel to identify and diagnose this rare mucocutaneous lesion. Two unique cases of oral MMP with varied clinical presentation, the diagnostic modality, treatment and follow-up are presented.

摘要

黏膜类天疱疮（MMP）是一组异质性自身免疫性慢性炎症性上皮下疱性疾病，主要累及黏膜。该病好发于女性，常见于50岁以后。超过90%的病例会累及口腔黏膜。牙医可能是首批识别和诊断这种罕见黏膜皮肤病变的医护人员。本文介绍了两例临床表现各异的口腔MMP病例，以及其诊断方式、治疗和随访情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/80c8c22e8e18/JISP-20-630-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/152816d20719/JISP-20-630-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/14483adcdb75/JISP-20-630-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/0defc47db1e7/JISP-20-630-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/e793928b6e97/JISP-20-630-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/7eb5c7757238/JISP-20-630-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/0cc1ed24e7ce/JISP-20-630-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/80c8c22e8e18/JISP-20-630-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/152816d20719/JISP-20-630-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/14483adcdb75/JISP-20-630-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/0defc47db1e7/JISP-20-630-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/e793928b6e97/JISP-20-630-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/7eb5c7757238/JISP-20-630-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/0cc1ed24e7ce/JISP-20-630-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/5713088/80c8c22e8e18/JISP-20-630-g007.jpg

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本文引用的文献

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Urban legend series: mucous membrane pemphigoid.都市传说系列：黏膜类天疱疮
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2
Mucous membrane pemphigoid.黏膜类天疱疮
Dent Clin North Am. 2013 Oct;57(4):611-30. doi: 10.1016/j.cden.2013.07.003. Epub 2013 Aug 15.
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Interleukin-4RA gene polymorphism is associated with oral mucous membrane pemphigoid.白细胞介素-4受体基因多态性与口腔黏膜类天疱疮相关。
Bioinformation. 2020 Dec 31;16(12):992-998. doi: 10.6026/97320630016992. eCollection 2020.
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Prevalence and clinical significance of anti-laminin 332 autoantibodies detected by a novel enzyme-linked immunosorbent assay in mucous membrane pemphigoid.新型酶联免疫吸附试验检测黏膜性类天疱疮中抗层粘连蛋白 332 自身抗体的流行率及临床意义。
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Pemphigoid diseases.疱疹样疾病。
Lancet. 2013 Jan 26;381(9863):320-32. doi: 10.1016/S0140-6736(12)61140-4. Epub 2012 Dec 11.
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The management of mucous membrane pemphigoid and pemphigus.黏膜类天疱疮和天疱疮的治疗。
Dermatol Ther. 2010 May-Jun;23(3):268-80. doi: 10.1111/j.1529-8019.2010.01323.x.
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Oral mucosal diseases: mucous membrane pemphigoid.口腔黏膜疾病：类天疱疮。
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Eur J Dermatol. 2007 May-Jun;17(3):191-200. doi: 10.1684/ejd.2007.0148. Epub 2007 May 4.
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