通过邻苯二甲醛的内部氧化还原烯丙基化反应实现手性铱催化的邻苯二甲酸酐形成。
Enantioselective Iridium-Catalyzed Phthalide Formation through Internal Redox Allylation of Phthalaldehydes.
机构信息
University of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA.
出版信息
Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1390-1393. doi: 10.1002/anie.201712015. Epub 2018 Jan 4.
Abstract
An inside job: Enantioselective phthalide synthesis was achieved through internal redox allylation of o-phthalaldehydes. Oxidative esterification is balanced by reductive carbonyl addition to achieve an overall redox-neutral process. This method enabled formal syntheses of ent-spirolaxine methyl ether and CJ-12,954.
摘要
内部工作
通过邻苯二甲醛的内部氧化还原烯丙基化实现了对映选择性的苯酞合成。通过羰基的还原加成来平衡氧化酯化，以实现总体氧化还原中性过程。该方法可用于正式合成 ent-spirolaxine methyl ether 和 CJ-12,954。
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