Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.
Food Funct. 2018 Feb 21;9(2):740-757. doi: 10.1039/c7fo01551h.
The main goal of this work was to clarify the effects of the consumption of berries on cardiovascular disease (CVD) risk factors by performing a systematic review according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement, followed by a meta-analysis and a trial sequential analysis (TSA) of randomized controlled trials (RCTs). The electronic search was conducted in PubMed, Scopus, SciELO, Web of Science and Cochrane Library between April and June 2016. To be included, RCTs had to report 1 or more of the following outcomes: total cholesterol (TC), HDL-cholesterol (HDL), LDL-cholesterol (LDL), triglycerides (TG), blood pressure (BP), C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM), intercellular adhesion molecule-1 (ICAM), glucose, insulin, apolipoprotein A-I (Apo A-I) or apolipoprotein B (Apo B). It was observed that the intake of berries reduces TC, LDL, TG, and BP while increasing the level of HDL, suggesting a beneficial effect on the control of CVDs' risk factors. Thus, the intake of berries as nutraceuticals or functional foods could be suggested for the prevention and control of CVDs.
本研究旨在通过系统评价（PRISMA 声明）、荟萃分析和随机对照试验（RCT）的试验序贯分析（TSA），阐明浆果对心血管疾病（CVD）风险因素的影响。电子检索于 2016 年 4 月至 6 月在 PubMed、Scopus、SciELO、Web of Science 和 Cochrane Library 中进行。为了纳入研究，RCT 必须报告以下 1 个或多个结果：总胆固醇（TC）、高密度脂蛋白胆固醇（HDL）、低密度脂蛋白胆固醇（LDL）、甘油三酯（TG）、血压（BP）、C 反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、血管细胞黏附分子-1（VCAM）、细胞间黏附分子-1（ICAM）、葡萄糖、胰岛素、载脂蛋白 A-I（Apo A-I）或载脂蛋白 B（Apo B）。结果表明，摄入浆果可降低 TC、LDL、TG 和 BP，同时提高 HDL 水平，这表明浆果对控制 CVD 风险因素具有有益作用。因此，将浆果作为营养保健品或功能性食品摄入，可能有助于预防和控制 CVD。
