Slama Hichem, Chylinski Daphne Olivia, Deliens Gaétane, Leproult Rachel, Schmitz Rémy, Peigneux Philippe
UR2NF - Neuropsychology and Functional Neuroimaging Research Group at CRCN - Center for Research in Cognition and Neurosciences and UNI - ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
UNESCOG - Research Unit in Cognitive Neurosciences at CRCN - Center for Research in Cognition and Neurosciences and UNI - ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Sleep. 2018 Feb 1;41(2). doi: 10.1093/sleep/zsx200.
This study investigates the impact of sleep deprivation (SD) on task-goal switching, a key component of cognitive flexibility.
Task-goal switching performance was tested after one night of regular sleep (n = 17 participants) or of total SD (n = 18). To understand the relationships between task-switching performance and other cognitive processes following SD, participants were tested for other key attentional (alertness and vigilance) and executive (inhibition and working memory) functions. Spontaneous eye blink rate (EBR) was also measured as an indirect marker of striatal dopaminergic function.
SD negatively affects task-goal switching as well as attentional and inhibition measures, but not working memory. Changes in task-goal switching performance were not significantly correlated with changes in objective and subjective markers of fatigue and sleepiness, response inhibition, or spontaneous EBR.
Altogether, our results show differentiated effects of SD on key executive functions such as working memory, inhibition, and task-goal switching.
本研究调查睡眠剥夺（SD）对任务目标转换的影响，任务目标转换是认知灵活性的一个关键组成部分。
在经过一晚正常睡眠（n = 17名参与者）或完全睡眠剥夺（n = 18）后，测试任务目标转换表现。为了解睡眠剥夺后任务转换表现与其他认知过程之间的关系，对参与者进行了其他关键注意力（警觉性和警惕性）和执行功能（抑制和工作记忆）的测试。还测量了自发眨眼率（EBR）作为纹状体多巴胺能功能的间接指标。
睡眠剥夺对任务目标转换以及注意力和抑制测量有负面影响，但对工作记忆没有影响。任务目标转换表现的变化与疲劳和困倦、反应抑制或自发眨眼率的客观和主观指标的变化没有显著相关性。
总体而言，我们的结果显示了睡眠剥夺对工作记忆、抑制和任务目标转换等关键执行功能的不同影响。
