Singapore Centre for Environmental Life Sciences Engineering, 60 Nanyang Drive, Singapore 637551, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
Department of Immunology, Weizmann Institute of Science, 7610001 Rehovot, Israel.
Cell. 2017 Dec 14;171(7):1481-1493. doi: 10.1016/j.cell.2017.11.024.
The "holobiont" concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolving microbial-host associations and relations during distinct milestones across the lifespan of a human being. We discuss the current knowledge of biological symbiosis between the microbiome and its host and portray the challenges in understanding these interactions and their potential effects on human physiology, including microbiome-nervous system inter-relationship and its relevance to human variation and individuality.
“整体生物”概念被定义为真核生物和原核生物对多细胞生物的共同贡献，它为个体性提出了一个复杂的定义，使人们能够对人类进化和个性化特征有一个新的全面认识。在这里，我们提供了在人类生命周期的不同里程碑中，不断发展的微生物-宿主关联和关系的快照。我们讨论了微生物组与其宿主之间生物共生的现有知识，并描绘了理解这些相互作用及其对人类生理学的潜在影响的挑战，包括微生物组-神经系统的相互关系及其与人类变异和个性的关系。
