抗坏血酸：一种集中于人类胃液中的因子。

Ascorbic acid: a factor concentrated in human gastric juice.

Rathbone B J, Johnson A W, Wyatt J I, Kelleher J, Heatley R V, Losowsky M S

Department of Medicine, St James's University Hospital, Leeds, U.K.

Clin Sci (Lond). 1989 Mar;76(3):237-41. doi: 10.1042/cs0760237.

Abstract

Concentrations of ascorbic acid (ascorbic and dehydro-ascorbic; A + D; measured by the 2,4-dinitrophenylhydrazine method) of nearly three times those of plasma are present in gastric juice samples from patients with normal gastric histology. 2. A significant reduction in gastric juice ascorbic acid (A + D) was observed in patients with chronic gastritis. This reduction in concentration was independent of the grade of gastritis. 3. Concentrations of ascorbic acid (A + D) in gastric biopsy specimens were consistently higher in the antrum than in the body of the stomach. 4. These data demonstrate that considerable quantities of ascorbic acid (A + D) are normally 'secreted' into the stomach. 5. Ascorbic acid (ascorbic only; A; measured by h.p.l.c.) was present predominantly in its biologically active form in the patients with normal gastric histology. However, in patients with gastritis, independent of grade, ascorbic acid was present predominantly in its oxidized, biologically inactive form.

摘要

胃组织学正常患者的胃液样本中抗坏血酸（抗坏血酸和脱氢抗坏血酸；A + D；采用2,4 - 二硝基苯肼法测定）的浓度几乎是血浆浓度的三倍。2. 观察到慢性胃炎患者胃液中的抗坏血酸（A + D）显著降低。这种浓度降低与胃炎的严重程度无关。3. 胃活检标本中抗坏血酸（A + D）的浓度在胃窦部始终高于胃体部。4. 这些数据表明，相当数量的抗坏血酸（A + D）通常会“分泌”到胃中。5. 在胃组织学正常的患者中，抗坏血酸（仅抗坏血酸；A；采用高效液相色谱法测定）主要以其生物活性形式存在。然而，在胃炎患者中，无论严重程度如何，抗坏血酸主要以其氧化的、无生物活性的形式存在。