Nakamura Sachika, Okamoto Mariko R, Yamamoto Ken, Tsurumoto Akihisa, Yoshino Yoko, Iwabuchi Hiroshi, Saito Ichiro, Maeda Nobuko, Nakagawa Yoichi
Department of Clinical Pathophysiology., Tsurumi University School of Dental Medicine, Tsurumi University Dental Hospital, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.
Department of Oral Microbiology, Tsurumi University, School of Dental Medicine, Yokohama, Japan.
BMC Oral Health. 2017 Dec 16;17(1):153. doi: 10.1186/s12903-017-0449-3.
The purpose of this study was to clarify the species of Candida that are important for the development of atrophic glossitis in xerostomia patients.
A total of 231 patients with subjective dry mouth were enrolled in the present study. Logistic regression analysis was performed to clarify the contribution of each Candida species and other variables to the development of atrophic glossitis. The dependent variable was the absence/presence of atrophic glossitis. The Candida colony-forming units (CFU) of C. albicans, C. glabrata, C. tropicalis, and C. krusei, as well as age, gender, resting (RSFR) and stimulated (SSFR) whole salivary flow rate, and denture-wearing status, were treated as explanatory variables.
Logistic regression analysis showed that two factors were closely associated with the presence of atrophic glossitis: an increase in C. albicans CFU and a decrease in the SSFR.
C. albicans, but not non-albicans Candida, was associated with atrophic glossitis in xerostomia patients who had no systemic predisposing factors, indicating that C. albicans remains a treatment target for Candida-related atrophic glossitis.
本研究的目的是明确对口干症患者萎缩性舌炎的发生具有重要意义的念珠菌种类。
本研究共纳入231例主观感觉口干的患者。进行逻辑回归分析以明确每种念珠菌种类及其他变量对萎缩性舌炎发生的影响。因变量为萎缩性舌炎的有无。白色念珠菌、光滑念珠菌、热带念珠菌和克柔念珠菌的念珠菌菌落形成单位（CFU），以及年龄、性别、静息（RSFR）和刺激（SSFR）全唾液流速和戴假牙状况，均作为解释变量。
逻辑回归分析显示，有两个因素与萎缩性舌炎的存在密切相关：白色念珠菌CFU增加和SSFR降低。
在无全身易感因素的口干症患者中，与萎缩性舌炎相关的是白色念珠菌而非非白色念珠菌，这表明白色念珠菌仍是念珠菌相关萎缩性舌炎的治疗靶点。
