孕激素和睾酮的日常波动与纤维肌痛疼痛严重程度相关。
Daily Fluctuations of Progesterone and Testosterone Are Associated With Fibromyalgia Pain Severity.
机构信息
University of Alabama at Birmingham, Department of Psychology, Birmingham, Alabama.
University of Alabama at Birmingham, Department of Psychology, Birmingham, Alabama.
出版信息
J Pain. 2018 Apr;19(4):410-417. doi: 10.1016/j.jpain.2017.11.013. Epub 2017 Dec 14.
UNLABELLED
The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives. Cortisol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum. A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity. In the entire sample, day to day changes in progesterone (P = .002) as well as testosterone (P = .015) were significantly and inversely correlated with pain severity. There was no relationship between estradiol and pain (P = .551) or cortisol and pain (P = .633). These results suggest that progesterone and testosterone play a protective role in fibromyalgia pain severity. Sex and other hormones may serve to increase as well as decrease fibromyalgia pain severity.
PERSPECTIVE
Sex hormones fluctuate normally in women with fibromyalgia, but may still contribute to pain severity.
目的
本纵向采血研究旨在探讨性激素与纤维肌痛疼痛之间的关系。8 名符合纤维肌痛病例定义标准的女性提供了静脉血样，并在 25 天内连续报告其纤维肌痛疼痛严重程度。所有女性均表现出正常的月经周期，且未服用口服避孕药。从血清中检测了皮质醇以及性激素雌二醇、孕酮和睾酮。采用线性混合模型确定性激素的波动是否与疼痛严重程度的变化相关。在整个样本中，孕酮（P=0.002）和睾酮（P=0.015）的日变化与疼痛严重程度呈显著负相关。雌二醇与疼痛之间没有关系（P=0.551），皮质醇与疼痛之间也没有关系（P=0.633）。这些结果表明，孕酮和睾酮在纤维肌痛疼痛严重程度中起保护作用。性激素可能会增加也可能会降低纤维肌痛的疼痛严重程度。
观点
纤维肌痛女性的性激素会正常波动，但仍可能导致疼痛严重程度增加。
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