由上临界溶液温度聚合物调控的双响应性介孔二氧化硅纳米粒子用于细胞内药物递送
Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery.
作者信息
Hei Mingyang, Wang Jun, Wang Kelly, Zhu Weiping, Ma Peter X
机构信息
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China.
出版信息
J Mater Chem B. 2017 Dec 28;5(48):9497-9501. doi: 10.1039/c7tb02429k. Epub 2017 Nov 21.
Abstract
We synthesized a new type of upper critical solution temperature (UCST) thermally responsive polymers (TRPs) with varying responsive temperatures (cloud points). We then grafted one of the TRPs with a cloud point of 42°C on the surface of mesoporous silica nanoparticles (MSN) using disulfide bonds to achieve a novel, dual responsive release system. With this system, the cargo release profiles are responsive to both temperature and reducing agents. When loaded with doxorubicin hydrochloride (DOX), the system could deliver DOX into breast cancer cells (SK-BR-3) in a controlled fashion and present high toxicity.
摘要
我们合成了一种新型的具有不同响应温度（浊点）的上临界溶液温度（UCST）热响应聚合物（TRP）。然后，我们使用二硫键将一种浊点为42°C的TRP接枝到介孔二氧化硅纳米颗粒（MSN）表面，以实现一种新型的双响应释放系统。通过该系统，药物释放曲线对温度和还原剂均有响应。当负载盐酸阿霉素（DOX）时，该系统能够以可控方式将DOX递送至乳腺癌细胞（SK-BR-3）并呈现出高毒性。
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