Sheen I S, Liaw Y F
Liver Unit, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
Hepatology. 1989 Apr;9(4):538-40. doi: 10.1002/hep.1840090405.
To investigate the prevalence and incidence of cholecystolithiasis in hepatitis B surface antigen-positive chronic liver diseases, a prospective study using hepatobiliary ultrasonography was conducted in 933 "healthy" persons and four groups of HBsAg-positive patients: 226 asymptomatic carriers, 73 patients with chronic active hepatitis, 77 patients with early liver cirrhosis and 124 patients with advanced liver cirrhosis. Patients with hepatocellular carcinoma or alcoholism were excluded. The prevalences of cholecystolithiasis increased along with the increasing duration and severity of chronic liver diseases, with a significant linear trend (p less than 0.001). The prevalences of cholecystolithiasis in patients with liver cirrhosis (18.5% in males, 31.2% in females) were 4 to 5.5 times higher than that of the healthy population (p less than 0.005). In addition, the linear trend of increasing prevalence with increasing age in the healthy population was not observed in patients with chronic liver diseases. On the other hand, five of the 69 patients with early liver cirrhosis were found to develop cholecystolithiasis during a mean follow-up period of 32 months. The calculated annual incidence of cholecystolithiasis was 2.6%. The results suggest that chronic liver disease, particularly liver cirrhosis, is a risk factor for cholecystolithiasis.
为调查乙肝表面抗原阳性慢性肝病患者胆囊结石的患病率和发病率，我们对933名“健康”人群以及四组乙肝表面抗原阳性患者进行了一项使用肝胆超声的前瞻性研究：226名无症状携带者、73名慢性活动性肝炎患者、77名早期肝硬化患者和124名晚期肝硬化患者。排除了肝细胞癌或酗酒患者。胆囊结石的患病率随着慢性肝病病程和严重程度的增加而升高，呈显著线性趋势（p<0.001）。肝硬化患者的胆囊结石患病率（男性为18.5%，女性为31.2%）比健康人群高4至5.5倍（p<0.005）。此外，在慢性肝病患者中未观察到健康人群中随年龄增长患病率增加的线性趋势。另一方面，在69名早期肝硬化患者中，有5名在平均32个月的随访期内发生了胆囊结石。计算得出的胆囊结石年发病率为2.6%。结果表明，慢性肝病，尤其是肝硬化，是胆囊结石的一个危险因素。
