Zaccone G, Fasulo S, Ainis L, Contini A
Department of Animal Biology and Marine Ecology, Messina University, Italy.
Histochemistry. 1989;91(1):13-6. doi: 10.1007/BF00501904.
Calmodulin is a Ca2+-dependent modulatory protein which is required in the general regulation of a large number of key processes of cellular metabolism. In the present study, the localization of calmodulin positive immunoreactivity in the epidermis of the brown trout, Salmo trutta was investigated using a specific mouse monoclonal antibody to calmodulin of IgG2 class. The immunoreaction was found only in the superficial epithelial cells that constitute the main histological site for the production of calmodulin positive substances. Because of its distribution, this protein might have a physiological significance in the activation of the microvillar skeleton and in the control of the permeability of the skin epithelium.
钙调蛋白是一种依赖钙离子的调节蛋白，在细胞代谢的大量关键过程的总体调节中是必需的。在本研究中，使用针对IgG2类钙调蛋白的特异性小鼠单克隆抗体，研究了褐鳟（Salmo trutta）表皮中钙调蛋白阳性免疫反应的定位。免疫反应仅在构成钙调蛋白阳性物质产生的主要组织学部位的表层上皮细胞中发现。由于其分布情况，这种蛋白质可能在微绒毛骨架的激活以及皮肤上皮通透性的控制中具有生理意义。
