来自日本布雷格链霉菌亚种的新型醌霉素类抗生素UK-63,052复合物；分类学、发酵、分离、表征及抗菌活性

UK-63,052 complex, new quinomycin antibiotics from Streptomyces braegensis subsp. japonicus; taxonomy, fermentation, isolation, characterisation and antimicrobial activity.

作者信息

Rance M J, Ruddock J C, Pacey M S, Cullen W P, Huang L H, Jefferson M T, Whipple E B, Maeda H, Tone J

机构信息

Central Research Division, Pfizer Limited, Kent, England.

出版信息

J Antibiot (Tokyo). 1989 Feb;42(2):206-17. doi: 10.7164/antibiotics.42.206.

DOI:10.7164/antibiotics.42.206

PMID:2925512

Abstract

UK-63,052 complex, a new group of quinomycin-like antibiotics comprising UK-63,052 (factor A), UK-63,598 (factor C), UK-65,662 (factor B) and several uncharacterised minor components, is produced by a new subspecies of the genus Streptomyces for which the name Streptomyces braegensis Dietz subsp. japonicus, is proposed. The strain, N617-29, is characterised by a negative melanin reaction, grey aerial mycelium, spiral spore chains and smooth or slightly warty spores. Structure determination has identified UK-63,052, C56H68N10O14S2, UK-63,598, C53H62N10O14S2 and UK-65,662, C55H66N10O14S2 as quinaldic acid substituted quinomycins with unusual bridgehead sulfur substitution as shown in Fig. 3.

摘要

UK-63,052复合物是一组新的类醌霉素抗生素，包括UK-63,052（因子A）、UK-63,598（因子C）、UK-65,662（因子B）以及几种未鉴定的次要成分，由链霉菌属的一个新亚种产生，为此提出了名为日本布雷格链霉菌（Streptomyces braegensis Dietz subsp. japonicus）的名称。该菌株N617-29的特征为黑色素反应阴性、灰色气生菌丝体、螺旋形孢子链以及光滑或稍有疣状的孢子。结构测定已确定UK-63,052（C56H68N10O14S2）、UK-63,598（C53H62N10O14S2）和UK-65,662（C55H66N10O14S2）为喹哪啶酸取代的醌霉素，具有如图3所示的不寻常桥头硫取代。