Sawada Y, Tsuno T, Miyaki T, Naito T, Oki T
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
J Antibiot (Tokyo). 1989 Feb;42(2):242-53. doi: 10.7164/antibiotics.42.242.
Two new 16-membered macrolides, cirramycins F-1 and F-2, were isolated from the culture filtrate of a mutant strain B-1425 of Streptomyces cirratus JTB-3. The antibiotics were also produced by bio-transformation of cirramycin A1 using a blocked mutant strain A-0033. Structures of F-1 and F-2 have been elucidated by spectral interpretation and analysis of acid degradation products. Both involved isomeric modification of a neutral sugar; F-1 contained L-rhodinose, and F-2 L-amicetose. Based on spectral data, cirramycin F-1 and antibiotic A6888C were found to be identical. Cirramycins F-1 and F-2 are active against Gram-positive bacteria, but less active than cirramycin A1.
从卷曲链霉菌JTB - 3的突变菌株B - 1425的培养滤液中分离出两种新的16元大环内酯类化合物，卷枝霉素F - 1和F - 2。这两种抗生素也可通过使用阻断突变菌株A - 0033对卷枝霉素A1进行生物转化产生。通过光谱解析和酸降解产物分析阐明了F - 1和F - 2的结构。两者都涉及一种中性糖的异构化修饰；F - 1含有L - 鼠李糖，F - 2含有L - 胺丝糖。基于光谱数据，发现卷枝霉素F - 1与抗生素A6888C相同。卷枝霉素F - 1和F - 2对革兰氏阳性菌有活性，但活性低于卷枝霉素A1。
