Chaaya Monique, Phung Kieu, Atweh Samir, El Asmar Khalil, Karam Georges, Khoury Rose Mary, Ghandour Lilian, Ghusn Husam, Assaad Sarah, Prince Martin, Waldemar Gunhild
Department of Epidemiology and Population Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.
Department of Neurology, Danish Dementia Research Center, The Neuroscience Center, University of Copenhagen, Copenhagen, Denmark.
Prev Med Rep. 2017 Nov 24;9:1-5. doi: 10.1016/j.pmedr.2017.11.006. eCollection 2018 Mar.
Little evidence from the Arab region is available on dementia and its associated risk factors. This study is the first in Lebanon to examine the association between community older adults' socio-demographics and cardiovascular disease risk factors (CVDRF) and dementia in the aim of closing the knowledge gap. A cross-sectional household survey was conducted in 2013 in Beirut and two districts of Mount Lebanon with 502 older adults (65 years and above) and their informants. Data was collected on CVDRF and socio-demographics using structured questionnaires and dementia was assessed using the 10/66 Dementia Research Group validated tools. Multivariable analysis was done using a generalized estimating equation to account for cluster effect. Being older and perceiving personal income as insufficient significantly increased the odds of dementia [OR = 4.00 (95%CI = 1.46, 10.95); OR = 7.07 (1.84, 27.03); OR = 3.90 (1.58, 9.60)]. Having uncontrolled hypertension (versus no hypertension) was the only significant CVDRF that increased the odds of dementia [OR = 6.35 (1.60, 25.10)]. Interventions targeting uncontrolled hypertension that aim to increase awareness about proper management of this chronic condition would contribute to the needed preventive efforts against CVDRFs in response to dementia risk. Further research on the association between income sufficiency - one indicator of low socio-economic status - and dementia is warranted.
阿拉伯地区关于痴呆症及其相关风险因素的证据很少。本研究是黎巴嫩首次针对社区老年人的社会人口统计学特征与心血管疾病风险因素(CVDRF)和痴呆症之间的关联进行的研究,旨在填补知识空白。2013年在贝鲁特和黎巴嫩山的两个地区对502名老年人(65岁及以上)及其 informant 进行了横断面家庭调查。使用结构化问卷收集了关于CVDRF和社会人口统计学的数据,并使用10/66痴呆症研究小组验证的工具对痴呆症进行了评估。使用广义估计方程进行多变量分析以考虑聚类效应。年龄较大以及认为个人收入不足会显著增加患痴呆症的几率[比值比(OR)=4.00(95%置信区间(CI)=1.46,10.95);OR=7.07(1.84,27.03);OR=3.90(1.58,9.60)]。患有未控制的高血压(与无高血压相比)是唯一显著增加患痴呆症几率的CVDRF[OR=6.35(1.60,25.10)]。针对未控制的高血压进行干预,旨在提高对这种慢性病适当管理的认识,这将有助于应对痴呆症风险,开展针对CVDRF所需的预防工作。有必要对收入充足(社会经济地位低的一个指标)与痴呆症之间的关联进行进一步研究。