Thomas T, Fletcher S, Yeoh G C, Schreiber G
Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia.
J Biol Chem. 1989 Apr 5;264(10):5784-90.
During the acute phase response to inflammation the plasma concentration of some proteins, such as alpha(1-acid glycoprotein (AGP), increases dramatically. Since breakdown and remodeling of tissue is common to both nidation and inflammation we studied the tissue distribution and regulation of AGP mRNA levels during the embryonic development of the rat. High levels of mRNA coding for AGP were detected in the placenta during early fetal development. Expression of this mRNA was confined to the decidua and was first observed approximately 1 day after implantation when proliferation of the decidua is already well advanced. Maximum levels were attained about 5 days after implantation, after which the levels decreased rapidly. In contrast to the high levels of AGP mRNA in the decidua only very low levels were detected in fetal liver and visceral yolk sac, and there was only a small increase in the levels in maternal liver. Corticosteroid hormone responsiveness of AGP mRNA synthesis by hepatocytes appeared 3 days before birth. It is likely that the synthesis of AGP by the cells of the decidua is important in establishing the precisely controlled interaction between mother and embryo during nidation.
在对炎症的急性期反应过程中，某些蛋白质的血浆浓度会急剧增加，比如α1-酸性糖蛋白（AGP）。由于着床和炎症都存在组织分解与重塑现象，我们研究了大鼠胚胎发育过程中AGP mRNA水平的组织分布及其调控。在胎儿发育早期，胎盘内检测到高水平的编码AGP的mRNA。这种mRNA的表达局限于蜕膜，在着床后约1天首次观察到，此时蜕膜的增殖已经相当活跃。在着床后约5天达到最高水平，之后水平迅速下降。与蜕膜中高水平的AGP mRNA形成对比的是，在胎儿肝脏和内脏卵黄囊中仅检测到非常低的水平，并且母体肝脏中的水平仅有小幅增加。肝细胞合成AGP mRNA对皮质类固醇激素的反应性在出生前3天出现。蜕膜细胞合成AGP可能在着床期间建立母体与胚胎之间精确调控的相互作用中起重要作用。
