Bertsche Thilo, Neininger Martina Patrizia, Kaune Almuth, Schumacher Pia M, Dumeier Henriette K, Bernhard Matthias K, Syrbe Steffen, Kiess Wieland, Merkenschlager Andreas, Bertsche Astrid
Zentrum für Arzneimittelsicherheit und Klinische Pharmazie, Universität Leipzig.
Klinik und Poliklinik für Kinder und Jugendliche, Zentrum für pädiatrische Forschung, Universitätsklinikum Leipzig.
Klin Padiatr. 2018 Jan;230(1):5-12. doi: 10.1055/s-0043-120525. Epub 2017 Dec 19.
Expertise in a variety of fields is required for the diagnostic process of epilepsies in children and adolescents as well as for their treatment with anticonvulsants. Patients benefit in the process from the cooperation of different health care professionals. It is of critical importance for risks to be minimised and for the efficacy shown in controlled clinical trials to be maintained in routine conditions. In the first instance, drug prescription procedures, including the choice of anticonvulsants and combinations of drugs and dosing, have to be considered. The administration of drugs has, of course, also to be taken into account. Only if patients are given their anticonvulsants appropriately, the intended success of the therapy can be accomplished. Strategies aimed at improving drug administration have to be directed not only at nurses but also at parents, children and adolescents themselves, as well as caregivers in schools and children's day-care facilities. By providing theoretical teaching, practical training, and routinely including pharmacists in the therapeutic team, drug-related problems that may result in limited effectiveness and increased risks are prevented. As a result, drug (therapy) safety is not only qualitatively improved, but the degree of participation and quality of life of patients and families is improved as well.
儿童和青少年癫痫的诊断过程以及使用抗惊厥药物进行治疗需要多种领域的专业知识。在这个过程中，患者受益于不同医疗保健专业人员的合作。将风险降至最低，并在常规条件下保持在对照临床试验中显示的疗效，这至关重要。首先，必须考虑药物处方程序，包括抗惊厥药物的选择、药物组合和剂量。当然，药物的给药方式也必须予以考虑。只有当患者正确服用抗惊厥药物时，才能实现预期的治疗成功。旨在改善药物给药的策略不仅要针对护士，还要针对父母、儿童和青少年自身，以及学校和儿童日托机构的护理人员。通过提供理论教学、实践培训，并将药剂师常规纳入治疗团队，可以预防可能导致疗效受限和风险增加的药物相关问题。结果，不仅药物（治疗）安全性在质量上得到提高，患者及其家庭的参与程度和生活质量也得到改善。
