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听觉失匹配响应对毒蕈碱型乙酰胆碱受体与多巴胺受体功能变化的敏感性存在差异。

Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function.

机构信息

Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland.

Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.

出版信息

Elife. 2022 May 3;11:e74835. doi: 10.7554/eLife.74835.

DOI:10.7554/eLife.74835
PMID:35502897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9098218/
Abstract

The auditory mismatch negativity (MMN) has been proposed as a biomarker of NMDA receptor (NMDAR) dysfunction in schizophrenia. Such dysfunction may be caused by aberrant interactions of different neuromodulators with NMDARs, which could explain clinical heterogeneity among patients. In two studies (N = 81 each), we used a double-blind placebo-controlled between-subject design to systematically test whether auditory mismatch responses under varying levels of environmental stability are sensitive to diminishing and enhancing cholinergic vs. dopaminergic function. We found a significant drug × mismatch interaction: while the muscarinic acetylcholine receptor antagonist biperiden delayed and topographically shifted mismatch responses, particularly during high stability, this effect could not be detected for amisulpride, a dopamine D2/D3 receptor antagonist. Neither galantamine nor levodopa, which elevate acetylcholine and dopamine levels, respectively, exerted significant effects on MMN. This differential MMN sensitivity to muscarinic versus dopaminergic receptor function may prove useful for developing tests that predict individual treatment responses in schizophrenia.

摘要

听觉失匹配负波 (MMN) 已被提议作为精神分裂症 NMDA 受体 (NMDAR) 功能障碍的生物标志物。这种功能障碍可能是由于不同神经调质与 NMDAR 的异常相互作用引起的，这可以解释患者之间的临床异质性。在两项研究（每组 81 人）中，我们采用双盲安慰剂对照的被试间设计，系统地测试了在不同环境稳定性水平下，听觉失匹配反应对胆碱能和多巴胺能功能减弱和增强的敏感性。我们发现了一个显著的药物×失匹配相互作用：虽然毒蕈碱乙酰胆碱受体拮抗剂苯海索延迟并在地形上改变了失匹配反应，特别是在高稳定性时，但对于多巴胺 D2/D3 受体拮抗剂氨磺必利，则无法检测到这种效应。分别升高乙酰胆碱和多巴胺水平的加兰他敏和左旋多巴对 MMN 均未产生显著影响。这种对毒蕈碱与多巴胺受体功能的 MMN 敏感性的差异可能有助于开发用于预测精神分裂症个体治疗反应的测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f129/9098218/2bb334bdf0e8/elife-74835-app2-fig2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f129/9098218/8c3bada017b4/elife-74835-fig2-figsupp1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f129/9098218/2f364a7b2b81/elife-74835-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f129/9098218/552103a40055/elife-74835-app1-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f129/9098218/0a2df5f3568b/elife-74835-app1-fig2.jpg
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本文引用的文献

1
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2
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Neuroimage. 2021 Aug 15;237:118096. doi: 10.1016/j.neuroimage.2021.118096. Epub 2021 May 1.
3
Statistical Learning and Inference Is Impaired in the Nonclinical Continuum of Psychosis.
Model-Based Approaches to Investigating Mismatch Responses in Schizophrenia.
基于模型的精神分裂症失配反应研究方法。
Clin EEG Neurosci. 2025 Jan;56(1):8-21. doi: 10.1177/15500594241253910. Epub 2024 May 15.
4
M2 receptors are required for spatiotemporal sequence learning in mouse primary visual cortex.M2 受体对于空间时间序列学习在小鼠初级视觉皮层中是必需的。
J Neurophysiol. 2024 Jun 1;131(6):1213-1225. doi: 10.1152/jn.00016.2024. Epub 2024 Apr 17.
5
Cholinergic modulation of sensory perception and plasticity.胆碱能调制感觉感知和可塑性。
Neurosci Biobehav Rev. 2023 Sep;152:105323. doi: 10.1016/j.neubiorev.2023.105323. Epub 2023 Jul 17.
6
EEG mismatch responses in a multimodal roving stimulus paradigm provide evidence for probabilistic inference across audition, somatosensation, and vision.多模态漫游刺激范式中的 EEG 失匹配反应为听觉、躯体感觉和视觉之间的概率推理提供了证据。
Hum Brain Mapp. 2023 Jun 15;44(9):3644-3668. doi: 10.1002/hbm.26303. Epub 2023 Apr 17.
7
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Front Psychiatry. 2023 Jan 9;13:1100030. doi: 10.3389/fpsyt.2022.1100030. eCollection 2022.
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5
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6
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7
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8
Low levels of muscarinic M1 receptor-positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia.精神分裂症患者大脑皮质第 III 和第 V 层布罗德曼 9 区和 17 区的毒蕈碱 M1 受体阳性神经元数量减少。
J Psychiatry Neurosci. 2018 Aug;43(5):338-346. doi: 10.1503/jpn.170202.
9
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10
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J Neurosci. 2018 Apr 18;38(16):4020-4030. doi: 10.1523/JNEUROSCI.3365-17.2018. Epub 2018 Mar 26.