a Department of Pharmacology and Chemical Biology, Faculty of Basic Medicine , Shanghai Jiao Tong University School of Medicine , Shanghai , PR China.
b Department of Neurological Surgery , Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , PR China.
J Drug Target. 2018 Jun-Jul;26(5-6):398-406. doi: 10.1080/1061186X.2017.1419360. Epub 2017 Dec 27.
In recent years, lipid-coated calcium-phosphate (LCP) nanoparticle has been developed as a versatile platform for delivery of various therapeutics including gene, protein/peptide, chemotherapeutics and theranostic agents. The high endosomal escape, coupled with the ability to efficiently encapsulate phosphorylated drugs or prodrugs, make LCP become attractive vehicle for drug delivery. Additionally, the principle behind LCP formulation has also allowed rational design of LCP-derived nanoparticles (NPs) with other solid core or lipid membrane to overcome the various drug delivery barriers. Here, we briefly review the history of the development of LCP NPs, highlight the optimisations and modulations in the development process, and summarise the major applications of LCP NPs and LCP-derived NPs in drug delivery.
近年来，脂质包覆的钙磷（LCP）纳米颗粒已被开发为一种多功能平台，可用于递送各种治疗剂，包括基因、蛋白质/肽、化疗药物和治疗诊断剂。其高效的内涵体逃逸能力，加上能够有效包封磷酸化药物或前药的能力，使得 LCP 成为一种有吸引力的药物递送载体。此外，LCP 制剂背后的原理还允许对具有其他固体核或脂质膜的 LCP 衍生纳米颗粒（NPs）进行合理设计，以克服各种药物递送障碍。在这里，我们简要回顾了 LCP NPs 的发展历史，强调了在开发过程中的优化和调整，并总结了 LCP NPs 和 LCP 衍生 NPs 在药物递送中的主要应用。
