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中药方剂玉屏风与地氯雷他定联合治疗慢性荨麻疹的有效性和安全性：一项随机对照试验的系统评价和Meta分析

Effectiveness and Safety of the Combination of the Traditional Chinese Medicine Prescription Jade Screen and Desloratadine in the Treatment of Chronic Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

作者信息

Yuan Shao-Fei, Guan Jing-Zhi, Hao Yong, Chai Jian-Yuan, Gao Feng-Li, Shi Su-Qin, Wang Jian-Xin, He Jin, Shi Ji-Hai

机构信息

Pharmaceutical Department, The Second Affiliated Hospital of Baotou Medical College, No. 30 Hudemulin Road, Baotou, Inner Mongolia 014030, China.

Pharmaceutical Department, Inner Mongolia International Mongolian Hospital, No. 83 Daxue East Road, Hohhot, Inner Mongolia 010065, China.

出版信息

Evid Based Complement Alternat Med. 2017;2017:1390301. doi: 10.1155/2017/1390301. Epub 2017 Nov 12.

DOI:10.1155/2017/1390301
PMID:29259640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5702416/
Abstract

OBJECTIVE

The aim of this study is to systematically evaluate the clinical efficacy and safety of the traditional Chinese medicine prescription Jade Screen combined with desloratadine in the treatment of chronic urticaria.

METHODS

Two researchers independently conducted literature searches. The extracted data were analyzed using Rev Man 5.2.3 software. The established retrieval time range of the various databases was up to 15 March, 2017.

RESULTS

Sixteen randomized controlled trials were included in this study. The results of the meta-analysis showed that the total effective rate of using Jade Screen and desloratadine in combination to treat chronic urticaria was higher than that with desloratadine alone ( < 0.00001), while its recurrence rate ( < 0.00001) and symptom score ( = 0.006) were both significantly lower than the latter. The rate of adverse reaction in the combination group was lower than that when orally taking desloratadine alone ( = 0.74), and the serum level of total IgE in the combination group was lower than that when orally taking desloratadine alone ( = 0.82); however, the results of the rate of adverse reaction and the serum level of total IgE were insignificant.

CONCLUSION

Using Jade Screen and desloratadine together to treat chronic urticaria gains a better clinical effect than using desloratadine alone.

摘要

目的

本研究旨在系统评价中药玉屏风联合地氯雷他定治疗慢性荨麻疹的临床疗效及安全性。

方法

两名研究人员独立进行文献检索。使用Rev Man 5.2.3软件对提取的数据进行分析。各数据库设定的检索时间范围截至2017年3月15日。

结果

本研究纳入16项随机对照试验。荟萃分析结果显示，玉屏风联合地氯雷他定治疗慢性荨麻疹的总有效率高于单用 地氯雷他定（<0.00001），而其复发率（<0.00001）和症状评分（=0.006）均显著低于后者。联合组不良反应发生率低于单用 地氯雷他定口服（=0.74），联合组血清总IgE水平低于单用 地氯雷他定口服（=0.82）；然而，不良反应发生率和血清总IgE水平的结果无统计学意义。

结论

玉屏风联合地氯雷他定治疗慢性荨麻疹比单用 地氯雷他定具有更好的临床效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/1647f941de34/ECAM2017-1390301.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/89dae3adcd0b/ECAM2017-1390301.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/7a1cee245fdd/ECAM2017-1390301.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/df8b49261066/ECAM2017-1390301.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/fc6a0eed4114/ECAM2017-1390301.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/4b0a60ebdf6e/ECAM2017-1390301.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/c3d4f851378d/ECAM2017-1390301.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/ce0d51ae7814/ECAM2017-1390301.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/335081aa3522/ECAM2017-1390301.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/1647f941de34/ECAM2017-1390301.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/89dae3adcd0b/ECAM2017-1390301.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/7a1cee245fdd/ECAM2017-1390301.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/df8b49261066/ECAM2017-1390301.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/fc6a0eed4114/ECAM2017-1390301.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/4b0a60ebdf6e/ECAM2017-1390301.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/c3d4f851378d/ECAM2017-1390301.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/ce0d51ae7814/ECAM2017-1390301.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/335081aa3522/ECAM2017-1390301.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/5702416/1647f941de34/ECAM2017-1390301.009.jpg

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本文引用的文献

1
Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report.慢性自发性荨麻疹未满足的临床需求。GA²LEN 工作组报告。
Allergy. 2011 Mar;66(3):317-30. doi: 10.1111/j.1398-9995.2010.02496.x. Epub 2010 Nov 17.
2
EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria.EAACI/GA(2)LEN/EDF/WAO 指南：荨麻疹的管理。
Allergy. 2009 Oct;64(10):1427-1443. doi: 10.1111/j.1398-9995.2009.02178.x.
3
EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria.EAACI/GA(2)LEN/EDF/WAO 指南：荨麻疹的定义、分类和诊断。
Allergy. 2009 Oct;64(10):1417-1426. doi: 10.1111/j.1398-9995.2009.02179.x.
4
Chronic urticaria: an internet survey of health behaviours, symptom patterns and treatment needs in European adult patients.慢性荨麻疹：欧洲成年患者健康行为、症状模式及治疗需求的网络调查
Br J Dermatol. 2009 Mar;160(3):633-41. doi: 10.1111/j.1365-2133.2008.08920.x. Epub 2008 Nov 11.
5
Annual direct and indirect health care costs of chronic idiopathic urticaria: a cost analysis of 50 nonimmunosuppressed patients.慢性特发性荨麻疹的年度直接和间接医疗保健费用：50例非免疫抑制患者的成本分析
Arch Dermatol. 2008 Jan;144(1):35-9. doi: 10.1001/archdermatol.2007.5.
6
Quality of life and patients' satisfaction in chronic urticaria and respiratory allergy.慢性荨麻疹和呼吸道过敏患者的生活质量及满意度
Allergy. 2003 Jul;58(7):621-3. doi: 10.1034/j.1398-9995.2003.00091.x.
7
[Progress in the immunopharmacological study of yupingfeng powder].[玉屏风散免疫药理学研究进展]
Zhongguo Zhong Yao Za Zhi. 1998 Aug;23(8):505-7.
8
Desloratadine: A new, nonsedating, oral antihistamine.地氯雷他定：一种新型的、无镇静作用的口服抗组胺药。
J Allergy Clin Immunol. 2001 Apr;107(4):751-62. doi: 10.1067/mai.2001.114239.
9
The impact of chronic urticaria on the quality of life.慢性荨麻疹对生活质量的影响。
Br J Dermatol. 1997 Feb;136(2):197-201.