Johansson C, Lausmaa J, Ask M, Hansson H A, Albrektsson T
Department of Handicap Research, University of Göteborg, Sweden.
J Biomed Eng. 1989 Jan;11(1):3-8. doi: 10.1016/0141-5425(89)90158-1.
Commercially pure (CP) titanium and Ti 6Al 4V alloy were sputtered onto polycarbonate plastic implants to analyse hard tissue reactions to the two metals. The implants were inserted in the tibial metaphyses of five rabbits. Three months later they were removed and processed for light microscopy (LM) and transmission electron microscopy (TEM) investigations. At the LM level, disordered woven bone was seen in the interface zone of Ti 6Al 4V, whereas organized bone was observed in direct contact with the CP titanium implants. TEM examination of Ti 6Al 4V sections revealed a 500-1000 A thick collagen-free proteoglycan layer compared to 200-400 A for CP titanium. A surface analysis test was performed to compare the magnetron sputtered film with bulk Ti 6Al 4V alloy. This test revealed no major differences between the experimental implant and the bulk alloy. More natural-like tissue reactions were observed to CP titanium than to Ti 6Al 4V alloy.
将工业纯（CP）钛和Ti 6Al 4V合金溅射至聚碳酸酯塑料植入物上，以分析硬组织对这两种金属的反应。将植入物植入五只兔子的胫骨干骺端。三个月后将它们取出并进行处理，用于光学显微镜（LM）和透射电子显微镜（TEM）研究。在光学显微镜水平上，在Ti 6Al 4V的界面区域可见无序的编织骨，而在与CP钛植入物直接接触处观察到有序骨。对Ti 6Al 4V切片的透射电子显微镜检查显示，有一层500 - 1000埃厚的无胶原蛋白聚糖层，而CP钛的该层厚度为200 - 400埃。进行了表面分析测试，以比较磁控溅射膜与块状Ti 6Al 4V合金。该测试表明实验植入物与块状合金之间没有重大差异。观察到与Ti 6Al 4V合金相比，CP钛引起的组织反应更接近自然状态。
