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RecQ 和 Fe-S 解旋酶在 DNA 代谢中具有独特的作用，这取决于它们的解旋方向、底物特异性和蛋白相互作用。

RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.

机构信息

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, U.S.A.

出版信息

Biochem Soc Trans. 2018 Feb 19;46(1):77-95. doi: 10.1042/BST20170044. Epub 2017 Dec 22.

DOI:10.1042/BST20170044
PMID:29273621
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5863537/
Abstract

Helicases are molecular motors that play central roles in nucleic acid metabolism. Mutations in genes encoding DNA helicases of the RecQ and iron-sulfur (Fe-S) helicase families are linked to hereditary disorders characterized by chromosomal instabilities, highlighting the importance of these enzymes. Moreover, mono-allelic RecQ and Fe-S helicase mutations are associated with a broad spectrum of cancers. This review will discuss and contrast the specialized molecular functions and biological roles of RecQ and Fe-S helicases in DNA repair, the replication stress response, and the regulation of gene expression, laying a foundation for continued research in these important areas of study.

摘要

解旋酶是在核酸代谢中起核心作用的分子马达。编码 RecQ 和铁硫 (Fe-S) 解旋酶家族的 DNA 解旋酶的基因突变与染色体不稳定性为特征的遗传性疾病有关，这突出了这些酶的重要性。此外，单等位基因 RecQ 和 Fe-S 解旋酶突变与广泛的癌症有关。本综述将讨论和对比 RecQ 和 Fe-S 解旋酶在 DNA 修复、复制应激反应和基因表达调控中的特殊分子功能和生物学作用，为这些重要研究领域的进一步研究奠定基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/c5cebfce7341/nihms948471f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/ab0d57144471/nihms948471f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/e8d5032c85b9/nihms948471f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/ba0669439f49/nihms948471f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/c5cebfce7341/nihms948471f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/ab0d57144471/nihms948471f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/e8d5032c85b9/nihms948471f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/ba0669439f49/nihms948471f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec9/5863537/c5cebfce7341/nihms948471f4.jpg

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本文引用的文献

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Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.靶向 DNA 修复和 DNA 修复缺陷的小分子抑制剂在研究和癌症治疗中的应用。
Cell Chem Biol. 2017 Sep 21;24(9):1101-1119. doi: 10.1016/j.chembiol.2017.08.027.
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Emerging functions of the Fanconi anemia pathway at a glance.范可尼贫血通路的新功能概览。
J Cell Sci. 2017 Aug 15;130(16):2657-2662. doi: 10.1242/jcs.204909.
3
SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.SIRT7 和 DEAD-box 解旋酶 DDX21 合作解决基因组 R 环并维护基因组稳定性。
Genes Dev. 2017 Jul 1;31(13):1370-1381. doi: 10.1101/gad.300624.117. Epub 2017 Aug 8.
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The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.人类 RecQ4 的结构与功能特征揭示了其解旋酶机制的相关见解。
Nat Commun. 2017 Jun 27;8:15907. doi: 10.1038/ncomms15907.
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Recent insights into the molecular basis of Fanconi anemia: genes, modifiers, and drivers.范可尼贫血分子基础的最新见解：基因、修饰因子和驱动因素。
Int J Hematol. 2017 Sep;106(3):335-344. doi: 10.1007/s12185-017-2283-4. Epub 2017 Jun 19.
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Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism.DNA解旋酶和转位酶与单链DNA结合蛋白RPA在核酸代谢中的相互作用角色
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