Kim Se Eun, Shim Kyung Mi, Jang Kwangsik, Shim Jin-Hyung, Kang Seong Soo
Biomaterial R&BD Center, Chonnam National University, Gwangju, Republic of Korea.
Department of Veterinary surgery, College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University, Gwangju, Republic of Korea.
In Vivo. 2018 Jan-Feb;32(1):63-70. doi: 10.21873/invivo.11205.
Three-dimensional (3D) printing has been applied extensively not only in human, but also veterinary medicine. However, the technique is still used in the clinical area for a surgical plan or education prior to surgery. Thus, we report a case of reconstruction after tumor removal surgery with the use of a 3D-printed scaffold. A 12-year-old female mixed dog had a left caudal maxillary mass. Based on computed tomography images, a defect was confirmed on the maxillary bone due to the oral mass, and a surgical plan was designed to remove the oral mass and graft the 3D printed scaffold. Customized polycaprolactone/ beta-tracalciumphosphate (PCL/β-TCP) scaffold was fabricated using the micro-extrusion-based 3D printer. In the operation, after the removal of the oral mass, the scaffold was grafted onto the defect site. At follow-up, 8 months after surgery, the result was successful without any special problems in the periodic CT scans and oral examinations. This case is believed to be the first case of reconstruction by using a 3D printed scaffold in the maxillary bone defect, and this 3D printing technique is thought to be very helpful for veterinary patients with bone defects and several other diseases.
三维(3D)打印不仅在人类医学,而且在兽医学中都得到了广泛应用。然而,该技术在临床领域仍仅用于手术计划或术前教育。因此,我们报告了一例使用3D打印支架进行肿瘤切除术后重建的病例。一只12岁的雌性混种犬左侧上颌尾部有肿物。根据计算机断层扫描图像,确认由于口腔肿物导致上颌骨出现缺损,并设计了手术方案来切除口腔肿物并植入3D打印支架。使用基于微挤压的3D打印机制作了定制的聚己内酯/β-磷酸三钙(PCL/β-TCP)支架。手术中,切除口腔肿物后,将支架植入缺损部位。在术后8个月的随访中,定期CT扫描和口腔检查结果显示成功,没有任何特殊问题。据信,该病例是上颌骨缺损使用3D打印支架进行重建的首例,并且这种3D打印技术被认为对患有骨缺损和其他几种疾病的兽医患者非常有帮助。