Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576 104, India.
AAPS PharmSciTech. 2022 Mar 17;23(4):92. doi: 10.1208/s12249-022-02242-8.
The gemstone of 3-dimensional (3D) printing shines up from the pyramid of additive manufacturing. Three-dimensional bioprinting technology has been predicted to be a game-changing breakthrough in the pharmaceutical industry since the last decade. It is fast evolving and finds its seats in a variety of domains, including aviation, defense, automobiles, replacement components, architecture, movies, musical instruments, forensic, dentistry, audiology, prosthetics, surgery, food, and fashion industry. In recent years, this miraculous manufacturing technology has become increasingly relevant for pharmaceutical purposes. Computer-aided drug (CAD) model will be developed by computer software and fed into bioprinters. Based on material inputs, the printers will recognize and produce the model scaffold. Techniques including stereolithography, selective laser sintering, selective laser melting, material extrusion, material jetting, inkjet-based, fused deposition modelling, binder deposition, and bioprinting expedite the printing process. Distinct advantages are rapid prototyping, flexible design, print on demand, light and strong parts, fast and cost-effective, and environment friendly. The present review gives a brief description of the conceptional 3-dimensional printing, followed by various techniques involved. A short note was explained about the fabricating materials in the pharmaceutical sector. The beam of light is thrown on the various applications in the pharma and medical arena.
3D 打印的宝石从增材制造的金字塔中闪耀出来。自上一个十年以来,三维生物打印技术一直被预测为制药行业的变革性突破。它发展迅速,在航空、国防、汽车、替代部件、建筑、电影、乐器、法医、牙科、听力学、义肢、手术、食品和时尚等多个领域都有一席之地。近年来,这项神奇的制造技术在制药方面的应用越来越多。计算机辅助药物 (CAD) 模型将由计算机软件开发,并输入生物打印机。根据材料输入,打印机将识别并生成模型支架。立体光刻、选择性激光烧结、选择性激光熔化、材料挤出、材料喷射、喷墨、熔融沉积建模、粘结剂沉积和生物打印等技术加快了打印过程。快速成型、灵活设计、按需打印、轻巧坚固的部件、快速且具有成本效益、环保是其显著优势。本综述简要描述了概念性的 3D 打印,然后介绍了所涉及的各种技术。还简要介绍了制药领域中使用的制造材料。最后探讨了 3D 打印在制药和医疗领域的各种应用。