Department of Radiology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Norway.
Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Comput Med Imaging Graph. 2018 Jan;63:24-30. doi: 10.1016/j.compmedimag.2017.12.002. Epub 2017 Dec 15.
Magnetic Resonance Imaging (MRI) of the prostate provides useful in vivo diagnostic tissue information such as tumor location and aggressiveness, but ex vivo histopathology remains the ground truth. There are several challenges related to the registration of MRI to histopathology. We present a method for registration of standard clinical T2-weighted MRI (T2W-MRI) and transverse histopathology whole-mount (WM) sections of the prostate.
An isotropic volume stack was created from the WM sections using 2D rigid and deformable registration combined with linear interpolation. The prostate was segmented manually from the T2W-MRI volume and registered to the WM section volume using a combination of affine and deformable registration. The method was evaluated on a set of 12 patients who had undergone radical prostatectomy. Registration accuracy was assessed using volume overlap (Dice Coefficient, DC) and landmark distances.
The DC was 0.94 for the whole prostate, 0.63 for the peripheral zone and 0.77 for the remaining gland. The landmark distances were on average 5.4 mm.
The volume overlap for the whole prostate and remaining gland, as well as the landmark distances indicate good registration accuracy for the proposed method, and shows that it can be highly useful for registering clinical available MRI and WM sections of the prostate.
前列腺磁共振成像（MRI）可提供有用的活体诊断组织信息，如肿瘤位置和侵袭性，但离体组织病理学仍然是金标准。MRI 与组织病理学配准存在几个挑战。我们提出了一种用于注册标准临床 T2 加权 MRI（T2W-MRI）和前列腺横向全切片组织病理学（WM）的方法。
使用二维刚性和变形配准结合线性插值，从 WM 切片创建各向同性体积堆栈。手动从 T2W-MRI 体积中分割前列腺，并使用仿射和变形配准的组合将其与 WM 切片体积进行配准。该方法在 12 例接受根治性前列腺切除术的患者中进行了评估。使用体积重叠（Dice 系数，DC）和标志点距离评估配准准确性。
整个前列腺的 DC 为 0.94，周围区为 0.63，其余腺体为 0.77。标志点距离平均为 5.4mm。
整个前列腺和剩余腺体的体积重叠以及标志点距离表明该方法具有良好的配准准确性，表明它可高度用于注册临床可用的 MRI 和前列腺 WM 切片。
