Cappellari Alberto M, Brizio Carolina, Mazzoni Marta B, Bertolozzi Giuseppe, Vianello Federica, Rocchi Alessia, Belli Massimo, Nossa Andrea, Consonni Dario, Milani Gregorio P, Fossali Emilio F
Department of Neuroscience, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Department of Pediatric Emergency, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Clinica De Marchi, Milan, Italy.
Brain Dev. 2018 Apr;40(4):311-315. doi: 10.1016/j.braindev.2017.12.004. Epub 2017 Dec 23.
To define the role of the EEG in predicting recurrence of febrile seizures (FS) in children after a first FS.
Children with a first simple or complex FS who underwent EEG at our hospital were retrospectively enrolled. EEG recordings were classified in three groups: normal, abnormal (slow activity or epileptiform discharges), and pseudo-petit mal discharge (PPMD) pattern. Children were followed-up for at least three years.
A total of 126 patients met the entry criteria, and 113 of them completed the follow-up. Risk of FS recurrence decreased linearly with increasing age (-2% per month). The risk was higher among patients with PPMD pattern (absolute risk 86%, adjusted relative risk 2.00) and abnormal EEG (epileptiform discharges: absolute risk 71%, adjusted relative risk 2.00; slow activity: absolute risk 56%, adjusted relative risk 1.44), compared with those with normal EEG (absolute risk 41%).
PPMD and abnormal EEG should be considered as an independent risk factor for FS recurrence.
明确脑电图（EEG）在预测儿童首次热性惊厥（FS）后复发中的作用。
回顾性纳入在我院接受EEG检查的首次发生单纯性或复杂性FS的儿童。EEG记录分为三组：正常、异常（慢波活动或癫痫样放电）和假小发作放电（PPMD）模式。对儿童进行至少三年的随访。
共有126例患者符合纳入标准，其中113例完成随访。FS复发风险随年龄增长呈线性下降（每月-2%）。与EEG正常的患者（绝对风险41%）相比，PPMD模式患者（绝对风险86%，校正相对风险2.00）和EEG异常（癫痫样放电：绝对风险71%，校正相对风险2.00；慢波活动：绝对风险56%，校正相对风险1.44）患者的复发风险更高。
PPMD和EEG异常应被视为FS复发的独立危险因素。
