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铁硫簇生物发生的 SUF 机制：接近分子机制的理解。

Iron-sulfur clusters biogenesis by the SUF machinery: close to the molecular mechanism understanding.

机构信息

Laboratoire de Chimie et Biologie des Métaux, Biocat, Université Grenoble Alpes, Grenoble, France.

Laboratoire de Chimie et Biologie des Métaux, CNRS, BioCat, UMR 5249, Grenoble, France.

出版信息

J Biol Inorg Chem. 2018 Jun;23(4):581-596. doi: 10.1007/s00775-017-1527-3. Epub 2017 Dec 26.

DOI:10.1007/s00775-017-1527-3
PMID:29280002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6006206/
Abstract

Iron-sulfur clusters (Fe-S) are amongst the most ancient and versatile inorganic cofactors in nature which are used by proteins for fundamental biological processes. Multiprotein machineries (NIF, ISC, SUF) exist for Fe-S cluster biogenesis which are mainly conserved from bacteria to human. SUF system (sufABCDSE operon) plays a general role in many bacteria under conditions of iron limitation or oxidative stress. In this mini-review, we will summarize the current understanding of the molecular mechanism of Fe-S biogenesis by SUF. The advances in our understanding of the molecular aspects of SUF originate from biochemical, biophysical and recent structural studies. Combined with recent in vivo experiments, the understanding of the Fe-S biogenesis mechanism considerably moved forward.

摘要

铁硫簇（Fe-S）是自然界中最古老和用途最广泛的无机辅因子之一，被蛋白质用于基本的生物过程。多蛋白机器（NIF、ISC、SUF）存在于 Fe-S 簇的生物发生中，主要从细菌到人类都保守。SUF 系统（sufABCDSE 操纵子）在铁限制或氧化应激条件下在许多细菌中发挥一般作用。在这篇迷你综述中，我们将总结 SUF 参与 Fe-S 生物发生的分子机制的最新认识。我们对 SUF 分子方面的理解的进展源于生化、生物物理和最近的结构研究。结合最近的体内实验，Fe-S 生物发生机制的理解取得了相当大的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/49c91c13abe8/775_2017_1527_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/0a0f3f76b552/775_2017_1527_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/65578a706dbb/775_2017_1527_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/e4cf12e7b7c4/775_2017_1527_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/01504708784c/775_2017_1527_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/955046e6aa99/775_2017_1527_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/d167172e1ee9/775_2017_1527_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/49c91c13abe8/775_2017_1527_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/0a0f3f76b552/775_2017_1527_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/65578a706dbb/775_2017_1527_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/e4cf12e7b7c4/775_2017_1527_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/01504708784c/775_2017_1527_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/955046e6aa99/775_2017_1527_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/d167172e1ee9/775_2017_1527_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/6006206/49c91c13abe8/775_2017_1527_Fig7_HTML.jpg

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