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环子孢子蛋白存活分析法的改进概述——一种检测青蒿素耐药性的新型表型分析法

Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant .

机构信息

Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming Yunnan 650500, China.

Biomedical Engineering Research Center, Kunming Medical University, Kunming Yunnan 650500, China.

出版信息

Zool Res. 2017 Nov 18;38(6):317-320. doi: 10.24272/j.issn.2095-8137.2017.075.

DOI:10.24272/j.issn.2095-8137.2017.075
PMID:29280362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5767555/
Abstract

Artemisinin resistance in threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.

摘要

青蒿素耐药性在 威胁着全球青蒿素联合疗法的显著疗效。因此，使用监测工具深入了解耐药机制至关重要。环早期生存测定法用于表型分析青蒿素耐药性或青蒿素敏感性降低。在此，我们综述了该测定方法的进展，并探讨了其局限性和潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88c/5767555/d5f8ad31341e/ZoolRes-38-6-317-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88c/5767555/d5f8ad31341e/ZoolRes-38-6-317-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88c/5767555/d5f8ad31341e/ZoolRes-38-6-317-g1.jpg

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