Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
Physiology.
J Strength Cond Res. 2018 Nov;32(11):3207-3215. doi: 10.1519/JSC.0000000000002348.
Wołyniec, W, Ratkowski, W, Kasprowicz, K, Jastrzębski, Z, Małgorzewicz, S, Witek, K, Grzywacz, T, Żmijewski, P, and Renke, M. Glomerular filtration rate is unchanged by ultramarathon. J Strength Cond Res 32(11): 3207-3215, 2018-Acute kidney injury (AKI) is reported as a common complication of marathon and ultramarathon running. In previous studies, AKI was diagnosed on the basis of the creatinine level in serum and estimated glomerular filtration rate (eGFR). In this study, we calculated eGFR and also measured creatinine clearance after every 25 km of a 100-km run. Twenty healthy, amateur runners (males, mean age 40.75 ± 7.15 years, mean body mass 76.87 ± 8.39 kg) took part in a 100-km run on a track. Blood and urine were collected before the run, after every 25 km, and 12 hours after the run. Seventeen runners completed the study. There was increase in creatinine, urea, and uric acid observed after 100 km (p < 0.05). The mean increase in creatinine was 0.21 mg·dl (24.53%). Five runners fulfilled the AKI network criteria of AKI. The eGFR according to the modification of diet in renal disease, chronic kidney disease epidemiology collaboration, and Cockcroft-Gault formulas was significantly decreased after the run (p ≤ 0.05). Otherwise, creatinine clearance calculated from creatinine level in both serum and urine remained stable. In contrast to the majority of previous studies, we did not observe any decrease in the kidney function during an ultramarathon. In this study, the creatinine clearance, which is the best routine laboratory method to determine GFR was used. There is no evidence that long running is harmful for kidney.
沃利涅茨，W，拉特科夫斯基，W，卡斯普罗维茨，K，亚斯特热布夫斯基，Z，马尔戈热维奇，S，维特克，K，格里瓦奇，T，日姆耶夫斯基，P，和伦克，M. 超级马拉松不会改变肾小球滤过率。J 力量与条件研究 32(11):3207-3215,2018-急性肾损伤 (AKI) 被报道为马拉松和超级马拉松跑步的常见并发症。在以前的研究中，AKI 是根据血清中肌酐水平和估计肾小球滤过率 (eGFR) 诊断的。在这项研究中，我们计算了 eGFR，并在 100 公里跑每 25 公里后测量了肌酐清除率。20 名健康的业余跑步者 (男性，平均年龄 40.75 ± 7.15 岁，平均体重 76.87 ± 8.39 公斤) 在赛道上参加了 100 公里跑。在跑步前、每 25 公里后和跑步后 12 小时采集了血液和尿液。17 名跑步者完成了这项研究。100 公里后观察到肌酐、尿素和尿酸升高 (p < 0.05)。肌酐平均增加 0.21 毫克·分升 (24.53%)。5 名跑步者符合 AKI 网络 AKI 标准。根据肾脏病饮食改良、慢性肾脏病流行病学合作和 Cockcroft-Gault 公式的 eGFR 在跑步后显著下降 (p ≤ 0.05)。否则，血清和尿液中肌酐水平计算的肌酐清除率保持稳定。与大多数以前的研究不同，我们在超级马拉松中没有观察到肾功能下降。在这项研究中，使用了肌酐清除率，这是一种确定 GFR 的最佳常规实验室方法。没有证据表明长跑对肾脏有害。
