Department of Medicine, University of Perugia Medical School, Perugia, Italy.
Gastroenterology and Hepatology Section, Santa Maria della Misericordia Hospital, Piazzale Menghini, 1, 06156, San Sisto (Perugia), Italy.
Cell Mol Life Sci. 2018 Apr;75(7):1145-1149. doi: 10.1007/s00018-017-2736-1. Epub 2017 Dec 28.
Post-infectious irritable bowel syndrome is a well-defined pathological entity that develops in about one-third of subjects after an acute infection (bacterial, viral) or parasitic infestation. Only recently it has been documented that an high incidence of post-infectious irritable bowel syndrome occurs after Clostridium difficile infection. However, until now it is not known why in some patients recovered from this infection the gastrointestinal disturbances persist for months or years. Based on our in vitro studies on enteric glial cells exposed to the effects of C. difficile toxin B, we hypothesize that persistence of symptoms up to the development of irritable bowel syndrome might be due to a disturbance/impairment of the correct functions of the enteroglial intestinal network.
感染后肠易激综合征是一种明确的病理实体，约三分之一的急性感染（细菌、病毒）或寄生虫感染后发生。最近有文献报道，艰难梭菌感染后感染后肠易激综合征的发生率很高。然而，到目前为止，尚不清楚为什么在一些从这种感染中康复的患者中，胃肠道紊乱会持续数月或数年。基于我们对暴露于艰难梭菌毒素 B 影响的肠神经胶质细胞的体外研究，我们假设症状持续存在直至发展为肠易激综合征可能是由于肠神经胶质肠道网络的正常功能发生紊乱/损伤。
