Department of Epidemiology and Biostatistics, Texas A&M University, College Station, TX, USA.
University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA.
Am J Reprod Immunol. 2018 Feb;79(2). doi: 10.1111/aji.12804. Epub 2017 Dec 29.
Toll-like (TLR) receptor genetic variants have been implicated in bacterial vaginosis (BV). We determined whether TLR variants are associated with fastidious BV-associated microbes that are linked with infertility following pelvic inflammatory disease (PID).
Sneathia spp., Atopobium vaginae, BVAB1, and Ureaplasma urealyticum were measured in 250 women from the PID Evaluation and Clinical Health (PEACH) study. Relative risk (RR) and 95% confidence intervals (CI) were calculated adjusting for chlamydia and gonorrhea. Principal component analysis was used to adjust for population stratification. A false discovery rate q-value of 0.05 was significant.
TLR2-1733C>A (P = .003) and TLR2-616A>G (P = .004) were associated with cervical A. vaginae. TLR2-1733C>A and TLR6-438C>T were associated with A. vaginae detection in the endometrium, but this was not significant after adjustment for multiple comparisons (FDR q-value = 0.06).
Host gene variants in TLR2 signaling pathways were modestly associated with cervical A. vaginae in women with clinical PID.
Toll 样（TLR）受体的遗传变异与细菌性阴道病（BV）有关。我们确定 TLR 变异是否与盆腔炎性疾病（PID）后与不孕相关的难辨梭状芽胞杆菌和 BVAB1 相关微生物有关。
在 PID 评估和临床健康（PEACH）研究中的 250 名女性中测量了 Sneathia spp.、阴道阿托波菌、BVAB1 和 Ureaplasma urealyticum。调整衣原体和淋病后，计算相对风险（RR）和 95%置信区间（CI）。主成分分析用于调整人群分层。错误发现率 q 值为 0.05 具有统计学意义。
TLR2-1733C>A（P=0.003）和 TLR2-616A>G（P=0.004）与宫颈 A. 阴道有关。TLR2-1733C>A 和 TLR6-438C>T 与子宫内膜中 A. 阴道的检测有关，但在进行多次比较调整后无统计学意义（FDR q 值=0.06）。
TLR2 信号通路中的宿主基因突变与 PID 女性的宫颈 A. 阴道有一定的关联。
