Department of Psychology, Brigham Young University, Provo, UT, United States; The Neuroscience Center, Brigham Young University, Provo, UT, United States.
Department of Psychology, Brigham Young University, Provo, UT, United States.
Psychiatry Res. 2018 Mar;261:73-79. doi: 10.1016/j.psychres.2017.12.037. Epub 2017 Dec 20.
Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C, influenza, varicella-zoster, and herpes viruses. In this study, we sought to evaluate further associations between viral exposure and depression. From the US Center for Disease Control's National Health and Nutrition Examination Survey, we obtained data about depression status, antidepressant use, exposure to hepatitis A, hepatitis B, herpes simplex virus type 1, herpes simplex virus type 2, human immunodeficiency virus, and cytomegalovirus, and sociodemographic variables and evaluated associations between depression and viral exposure in adjusted multivariable models. Herpes simplex virus type 2 was associated with an increased risk of depression, whereas hepatitis A, hepatitis B, and herpes simplex virus type 1 were not. Higher cytomegalovirus antibody levels were associated with depression in subjects seropositive for cytomegalovirus. In conclusion, exposure to herpes simplex virus type 2 and possibly cytomegalovirus are associated with depression in an adult US sample.
心境障碍是常见的精神疾病。与重度抑郁症相关的因素包括暴露于传染病，包括丙型肝炎、流感、水痘-带状疱疹和疱疹病毒。在这项研究中，我们试图进一步评估病毒暴露与抑郁症之间的关联。我们从美国疾病控制与预防中心的国家健康和营养检查调查中获得了有关抑郁症状况、抗抑郁药使用、甲型肝炎、乙型肝炎、单纯疱疹病毒 1 型、单纯疱疹病毒 2 型、人类免疫缺陷病毒和巨细胞病毒暴露以及社会人口统计学变量的数据，并在调整后的多变量模型中评估了抑郁症与病毒暴露之间的关联。单纯疱疹病毒 2 型与抑郁症的风险增加相关，而甲型肝炎、乙型肝炎和单纯疱疹病毒 1 型则没有。巨细胞病毒抗体水平较高与巨细胞病毒血清阳性者的抑郁有关。总之，在成年美国样本中，单纯疱疹病毒 2 型和可能巨细胞病毒的暴露与抑郁症有关。
