Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia; Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Pediatrics Infectious Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Microbes Infect. 2018 Oct-Nov;20(9-10):543-551. doi: 10.1016/j.micinf.2017.12.010. Epub 2017 Dec 26.
Human cytomegalovirus (HCMV) is the most common cause of viral infection acquired in utero. Even though the infection has been studied for several decades, immune determinants important for virus control and mechanisms of long-term sequelae caused by infection are still insufficiently characterized. Animal models of congenital HCMV infection provide unique opportunity to study various aspects of human disease. In this review, we summarize current knowledge on the role of immune system in congenital CMV infection, with emphasis on lessons learned from mouse model of congenital CMV infection.
人类巨细胞病毒（HCMV）是宫内获得性病毒感染的最常见原因。尽管这种感染已经研究了几十年，但对于控制病毒的免疫决定因素和感染引起的长期后遗症的机制仍了解不足。先天性 HCMV 感染的动物模型为研究人类疾病的各个方面提供了独特的机会。在这篇综述中，我们总结了免疫系统在先天性 CMV 感染中的作用的现有知识，重点介绍了从先天性 CMV 感染的小鼠模型中获得的经验教训。
