Department of Orthodontics, Narayana Dental College, Nellore, Andhra Pradesh 524003, India.
Department of Orthodontics, Faculty of Dentistry, University of Puthisastra, Phnom Penh 12211, Cambodia.
Biomed Res Int. 2022 Mar 20;2022:6828657. doi: 10.1155/2022/6828657. eCollection 2022.
The purpose of this randomized trial is to compare the efficacy of weekly once regime of neutral sodium fluoride (NaF) oral rinse with that of acidulated phosphate (APF) formulated daily mouth rinse in the reduction of white spot lesions (WSLs) associated with fixed orthodontic appliance treatment.
The participants ( = 90) of this single-center, two-arm parallel study without a control group were randomly assigned with 1 : 1 distribution to each of the two groups after the bonding of brackets. Group A/test group 1 ( = 45) was given weekly rinse of neutral sodium fluoride (0.2% NaF), and for group B/test group 2 ( = 45), an APF formulated daily oral rinse (-0.044% w/v of NaF) was given for six months. The outcome was assessed by the International Caries Detection and Assessment System (ICDAS) index for scoring the demineralization, and for scoring gingivitis, Loe and Silness gingival index (GI) was utilized. Four different time points "T0"immediately before bonding procedures, "T1" after 4weeks, "T2" after 12 weeks, and "T3" after 24 weeks were taken to assess the ICDAS and GI scores.
The mean ICDAS scores for group A (NaF) were 0.025, 0.051, 0.093, and 0.113 and for group B (APF) were 0.014, 0.022, 0.038, and 0.015 at different points of time. The GI scores for group A were 0.008, 0.22, 0.33, and 0.38 and for group B were 0.003, 0.136, 0.181, and 0.097 at different time points. There was a statistically significant difference ( < 0.05) for both groups in terms of reducing WSL and GI.
APF formulated daily oral rinse-0.044% w/v of NaF-is more effective than the weekly once regimen of 0.2% NaF oral rinse to prevent white spot lesions.
本随机试验的目的是比较每周一次中性氟化钠（NaF）漱口水与酸性磷酸（APF）配方每日漱口水在减少固定正畸治疗相关白垩斑（WSL）方面的疗效。
本单中心、双臂平行研究无对照组，参与者（n=90）在托槽粘接后按 1:1 随机分配到两组。A 组/试验组 1（n=45）给予每周一次中性氟化钠（0.2% NaF）漱口，B 组/试验组 2（n=45）给予 APF 配方每日口腔漱口（-0.044% w/v 的 NaF），持续 6 个月。采用国际龋病检测和评估系统（ICDAS）指数评估脱矿程度，采用 Loe 和 Silness 牙龈指数（GI）评估牙龈炎。在四个不同时间点“T0”（粘接前）、“T1”（4 周后）、“T2”（12 周后）和“T3”（24 周后）评估 ICDAS 和 GI 评分。
A 组（NaF）的平均 ICDAS 评分分别为 0.025、0.051、0.093 和 0.113，B 组（APF）分别为 0.014、0.022、0.038 和 0.015。A 组的 GI 评分分别为 0.008、0.22、0.33 和 0.38，B 组分别为 0.003、0.136、0.181 和 0.097。两组在减少 WSL 和 GI 方面均有统计学差异（<0.05）。
APF 配方每日口腔冲洗（-0.044% w/v 的 NaF）比每周一次的 0.2% NaF 口腔冲洗更有效，可预防白垩斑。
