从指令到输出：Wnt/PCP 信号在发育和癌症中的作用。
From instruction to output: Wnt/PCP signaling in development and cancer.
机构信息
Department of Cell, Developmental and Regenerative Biology and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Department of Cell, Developmental and Regenerative Biology and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
出版信息
Curr Opin Cell Biol. 2018 Apr;51:110-116. doi: 10.1016/j.ceb.2017.12.005. Epub 2017 Dec 29.
Abstract
Planar cell polarity (PCP) provides positional information to direct tissue patterning and morphogenesis. While much of the molecular detail of the pathway has been delineated in Drosophila, ensuing studies have shown considerable conservation of both the components and mechanisms of signaling in vertebrates. A recognized feature of PCP is the asymmetric localization of components that translates a global directional cue into a polarized downstream output. Here we discuss recent advances in the PCP field, from the organization of these asymmetric complexes to their upstream directional regulation by Wnt ligands. We also discuss the impact of Wnt/PCP signaling in disease and more specifically an emerging role in cancer progression.
摘要
平面细胞极性 (PCP) 为组织模式形成和形态发生提供位置信息。虽然果蝇中已经描述了该途径的大部分分子细节，但随后的研究表明，信号传导的成分和机制在脊椎动物中都有很大的保守性。PCP 的一个公认特征是成分的不对称定位，它将全局方向线索转化为极化的下游输出。在这里，我们讨论了 PCP 领域的最新进展，从这些不对称复合物的组织到 Wnt 配体对其上游方向的调节。我们还讨论了 Wnt/PCP 信号在疾病中的影响，特别是在癌症进展中的新兴作用。
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2
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