肝移植后非吻合胆道狭窄患者粪便微生物群落的特征。
Characteristics of fecal microbial communities in patients with non-anastomotic biliary strictures after liver transplantation.
机构信息
Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
Institute of Advanced Surgical Technology and Engineering, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
出版信息
World J Gastroenterol. 2017 Dec 14;23(46):8217-8226. doi: 10.3748/wjg.v23.i46.8217.
AIM
To explore the possible relationship between fecal microbial communities and non-anastomotic stricture (NAS) after liver transplantation (LT).
METHODS
A total of 30 subjects including 10 patients with NAS, 10 patients with no complications after LT, and 10 non-LT healthy individuals were enrolled. Fecal microbial communities were assessed by the 16S rRNA gene sequencing technology.
RESULTS
Different from the uncomplicated and healthy groups, unbalanced fecal bacterium ratio existed in patients with NAS after LT. The results showed that NAS patients were associated with a decrease of and and an increase of at the phylum level, with the proportion-ratio imbalance between potential pathogenic families including , , , and dominant families including .
CONCLUSION
The compositional shifts of the increase of potential pathogenic bacteria as well as the decrease of dominant bacteria might contribute to the incidence of NAS.
目的
探讨肝移植（LT）后粪便微生物群落与非吻合口狭窄（NAS）之间的可能关系。
方法
共纳入 30 名受试者，包括 10 例 NAS 患者、10 例 LT 后无并发症患者和 10 例非 LT 健康个体。采用 16S rRNA 基因测序技术评估粪便微生物群落。
结果
与无并发症和健康组不同，LT 后 NAS 患者的粪便细菌比例失衡。结果显示，NAS 患者与门水平上潜在致病家族数量减少和优势家族数量增加有关，包括 、 、 、 和 。
结论
潜在致病细菌的增加和优势细菌的减少可能导致 NAS 的发生。
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