Al-Rubeaan Khalid, Siddiqui Khalid, Alghonaim Mohammed, Youssef Amira M, AlNaqeb Dhekra
Dr. Khalid Al-Rubeaan, College of Medicine, King Saud University,, PO Box 18397, Riyadh 11415,, Saudi Arabia, T: 966.11-4786100 loc 5123,
Ann Saudi Med. 2018 Jan-Feb;38(1):46-56. doi: 10.5144/0256-4947.2018.03.01.1010. Epub 2018 Jan 3.
Saudi Arabia is facing an epidemic of type 2 diabetes that is complicated by a high rate of chronic complications such as kidney disease, which have a major impact on the healthcare system and economy. The Saudi diabetic kidney disease (SAUDI-DKD) study was launched to understand the implications of chronic diabetic kidney disease .
Examine the hematological, biochemical and metabolic parameters of the selected cohorts to look for biomarkers of diabetic nephropathy.
Cross-sectional, hospital-based.
Four general hospitals and two dialysis centers in Riyadh.
We recruited adult type 2 diabetic patients aged between 35 and 70 years, with a duration of diabetes > 10 years, including subjects with microalbuminuria, macroalbuminuria and end stage renal disease (ESRD). They were compared with subjects with normal albumin excretion classified according to American Diabetes Association (ADA) criteria.
The effect of different stages of diabetic nephropathy on hematological and biochemical parameters.
Of 427 subjects with nephropathy, 184 (43%) had microalbuminuria, 83 (19%) had macroalbu.minuria and 160 (37%) had end stage renal disease (ESRD). The remaining 213 (50%) subjects did not have nephropathy. Patients with nephropathy were older with a mean age (SD) of 55.62 (6.00) years and had a longer duration of diabetes (mean [SD], 19.04 [6.33]) years), and had a lower monthly income and body mass index (BMI) than patients without nephropathy. Insulin resistance, elevated uric acid level, low red blood cells (RBCs) count and low hemoglobin level were associated with significantly increased risk of macroalbuminuria and ESRD. Elevated uric acid and LDH were associated with significantly increased risk of microalbuminuria and ESRD, while elevated red blood cell distribution width was significantly associated with an increased risk of ESRD.
Diabetic nephropathy is associated with insulin resistance, changes in liver enzymes and uric acid in addition to abnormalities in the red blood cell count and red blood cell shape that warrant frequent monitoring among patients with diabetic kidney disease.
Cross-sectional study design and exclusion of patients with some risk factors.
沙特阿拉伯正面临2型糖尿病的流行，且伴有诸如肾病等慢性并发症的高发病率，这些并发症对医疗系统和经济产生了重大影响。沙特糖尿病肾病（SAUDI-DKD）研究旨在了解慢性糖尿病肾病的影响。
检查选定队列的血液学、生化和代谢参数，以寻找糖尿病肾病的生物标志物。
基于医院的横断面研究。
利雅得的四家综合医院和两家透析中心。
我们招募了年龄在35至70岁之间、糖尿病病程超过10年的成年2型糖尿病患者，包括微量白蛋白尿、大量白蛋白尿和终末期肾病（ESRD）患者。将他们与根据美国糖尿病协会（ADA）标准分类的白蛋白排泄正常的受试者进行比较。
糖尿病肾病不同阶段对血液学和生化参数的影响。
在427例肾病患者中，184例（43%）有微量白蛋白尿，83例（19%）有大量白蛋白尿，160例（37%）有终末期肾病（ESRD）。其余213例（50%）受试者没有肾病。肾病患者年龄较大，平均年龄（标准差）为55.62（6.00）岁，糖尿病病程较长（平均[标准差]，19.04[6.33]年），且月收入和体重指数（BMI）低于无肾病患者。胰岛素抵抗、尿酸水平升高、红细胞（RBC）计数低和血红蛋白水平低与大量白蛋白尿和ESRD风险显著增加相关。尿酸和乳酸脱氢酶升高与微量白蛋白尿和ESRD风险显著增加相关，而红细胞分布宽度升高与ESRD风险增加显著相关。
糖尿病肾病与胰岛素抵抗、肝酶和尿酸变化以及红细胞计数和红细胞形态异常有关，这需要对糖尿病肾病患者进行频繁监测。
横断面研究设计以及排除了一些有风险因素的患者。
