Matsumoto Akira, Miyahara Yuji
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Kanagawa Institute of Industrial Science and Technology (KISTEC-KAST), Kawasaki, Japan.
Sci Technol Adv Mater. 2017 Dec 19;19(1):18-30. doi: 10.1080/14686996.2017.1411143. eCollection 2018.
Boronic acids are well known for their ability to reversibly interact with the diol groups, a common motif of biomolecules including sugars and ribose. Due to their ability to interact with carbohydrates, they can be regarded as synthetic mimics of lectins, termed 'borono-lectins'. The borono-lectins can be tailored to elicit a broad profile of binding strength and specificity. This special property has been translated into many creative biomedical applications in a way interactive with biology. This review provides a brief overview of recent efforts of polymeric materials-based engineering taking advantage of such virtue of 'borono-lectins' chemistry, related to the field of biomaterials and drug delivery applications.
硼酸以其与二醇基团可逆相互作用的能力而闻名，二醇基团是包括糖和核糖在内的生物分子的常见结构基序。由于它们与碳水化合物相互作用的能力，它们可被视为凝集素的合成模拟物，称为“硼凝集素”。硼凝集素可以进行定制，以产生广泛的结合强度和特异性。这种特殊性质已通过与生物学相互作用的方式转化为许多创新性的生物医学应用。本综述简要概述了利用“硼凝集素”化学这一优点的基于聚合物材料的工程学的最新研究成果，这些成果与生物材料和药物递送应用领域相关。
