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急性淋巴细胞白血病的免疫疗法：从匮乏到富足。

Immunotherapy for acute lymphoblastic leukemia: from famine to feast.

作者信息

Davis Kara L, Mackall Crystal L

机构信息

Department of Pediatrics and.

Department of Medicine, Stanford University, Stanford, CA.

出版信息

Blood Adv. 2016 Dec 27;1(3):265-269. doi: 10.1182/bloodadvances.2016000034.

DOI:10.1182/bloodadvances.2016000034
PMID:29296941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5737176/
Abstract

This article has a companion Point by Jabbour and Kantarjian. Join in the discussion of these articles at Community Conversations.

摘要

本文有一篇由贾布尔和坎塔尔吉安撰写的配套观点文章。请在“社区对话”中参与对这些文章的讨论。

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本文引用的文献

1
Chimeric Antigen Receptor T cells for B Cell Neoplasms: Choose the Right CAR for You.用于B细胞肿瘤的嵌合抗原受体T细胞：为您选择合适的嵌合抗原受体
Curr Hematol Malig Rep. 2016 Oct;11(5):368-84. doi: 10.1007/s11899-016-0336-z.
2
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.CD19 CAR 免疫压力诱导 B 前体细胞急性淋巴细胞白血病谱系转换，揭示内在白血病可塑性。
Nat Commun. 2016 Jul 27;7:12320. doi: 10.1038/ncomms12320.
3
Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia.奥英妥珠单抗对比标准疗法治疗急性淋巴细胞白血病
N Engl J Med. 2016 Aug 25;375(8):740-53. doi: 10.1056/NEJMoa1509277. Epub 2016 Jun 12.
4
Blinatumomab, a Bispecific T-cell Engager (BiTE(®)) for CD-19 Targeted Cancer Immunotherapy: Clinical Pharmacology and Its Implications.博纳吐单抗，一种用于CD-19靶向癌症免疫治疗的双特异性T细胞衔接器（BiTE(®)）：临床药理学及其意义。
Clin Pharmacokinet. 2016 Oct;55(10):1271-1288. doi: 10.1007/s40262-016-0405-4.
5
Blinatumomab treatment of older adults with relapsed/refractory B-precursor acute lymphoblastic leukemia: Results from 2 phase 2 studies.博纳吐单抗治疗复发/难治性B前体急性淋巴细胞白血病老年患者：两项2期研究的结果
Cancer. 2016 Jul 15;122(14):2178-85. doi: 10.1002/cncr.30031. Epub 2016 May 3.
6
CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.成年B细胞急性淋巴细胞白血病患者中具有特定CD4+:CD8+组成的CD19嵌合抗原受体T细胞。
J Clin Invest. 2016 Jun 1;126(6):2123-38. doi: 10.1172/JCI85309. Epub 2016 Apr 25.
7
Lineage Switch in MLL-Rearranged Infant Leukemia Following CD19-Directed Therapy.CD19导向治疗后MLL重排婴儿白血病中的谱系转换
Pediatr Blood Cancer. 2016 Jun;63(6):1113-5. doi: 10.1002/pbc.25953. Epub 2016 Feb 23.
8
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Cancer Discov. 2015 Dec;5(12):1282-95. doi: 10.1158/2159-8290.CD-15-1020. Epub 2015 Oct 29.
9
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.工程共刺激结构设计决定肿瘤排斥动力学和 CAR T 细胞的持久性。
Cancer Cell. 2015 Oct 12;28(4):415-428. doi: 10.1016/j.ccell.2015.09.004.
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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors.4-1BB共刺激可改善嵌合抗原受体的持续性信号传导所诱导的T细胞耗竭。
Nat Med. 2015 Jun;21(6):581-90. doi: 10.1038/nm.3838. Epub 2015 May 4.