Mameli Chiara, Krakauer Nir Y, Krakauer Jesse C, Bosetti Alessandra, Ferrari Chiara Matilde, Moiana Norma, Schneider Laura, Borsani Barbara, Genoni Teresa, Zuccotti Gianvincenzo
Department of Pediatrics, V. Buzzi Children's Hospital, University of Milan, Milan, Italy.
Department of Civil Engineering, The City College of New York, New York, NY, United States of America.
PLoS One. 2018 Jan 3;13(1):e0190426. doi: 10.1371/journal.pone.0190426. eCollection 2018.
A Body Shape Index (ABSI) and normalized hip circumference (Hip Index, HI) have been recently shown to be strong risk factors for mortality and for cardiovascular disease in adults. We conducted an observational cross-sectional study to evaluate the relationship between ABSI, HI and cardiometabolic risk factors and obesity-related comorbidities in overweight and obese children and adolescents aged 2-18 years. We performed multivariate linear and logistic regression analyses with BMI, ABSI, and HI age and sex normalized z scores as predictors to examine the association with cardiometabolic risk markers (systolic and diastolic blood pressure, fasting glucose and insulin, total cholesterol and its components, transaminases, fat mass % detected by bioelectrical impedance analysis) and obesity-related conditions (including hepatic steatosis and metabolic syndrome). We recruited 217 patients (114 males), mean age 11.3 years. Multivariate linear regression showed a significant association of ABSI z score with 10 out of 15 risk markers expressed as continuous variables, while BMI z score showed a significant correlation with 9 and HI only with 1. In multivariate logistic regression to predict occurrence of obesity-related conditions and above-threshold values of risk factors, BMI z score was significantly correlated to 7 out of 12, ABSI to 5, and HI to 1. Overall, ABSI is an independent anthropometric index that was significantly associated with cardiometabolic risk markers in a pediatric population affected by overweight and obesity.
最近研究表明，体型指数（ABSI）和标准化臀围（臀围指数，HI）是成年人死亡和心血管疾病的重要危险因素。我们开展了一项观察性横断面研究，以评估2至18岁超重和肥胖儿童及青少年中ABSI、HI与心脏代谢危险因素及肥胖相关合并症之间的关系。我们以BMI、ABSI、HI年龄和性别标准化z分数作为预测因子进行多元线性和逻辑回归分析，以检验与心脏代谢风险标志物（收缩压和舒张压、空腹血糖和胰岛素、总胆固醇及其组分、转氨酶、生物电阻抗分析检测的体脂百分比）和肥胖相关病症（包括肝脂肪变性和代谢综合征）的关联。我们招募了217名患者（114名男性），平均年龄11.3岁。多元线性回归显示，ABSI z分数与15个以连续变量表示的风险标志物中的10个存在显著关联，而BMI z分数与9个显著相关，HI仅与1个显著相关。在预测肥胖相关病症和危险因素阈值以上值的多元逻辑回归中，BMI z分数与12个中的7个显著相关，ABSI与5个显著相关，HI与1个显著相关。总体而言，ABSI是一个独立的人体测量指数，在受超重和肥胖影响的儿科人群中与心脏代谢风险标志物显著相关。
