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人乳头瘤病毒及其基因型在土耳其中安纳托利亚高社会经济地位女性中的分布:一项初步研究。

Human Papilloma Viruses and Their Genotype Distribution in Women with High Socioeconomic Status in Central Anatolia, Turkey: A Pilot Study.

机构信息

Department of Obstetrics and Gynecology, Harran University School of Medicine, Şanlıurfa, Turkey.

Department of Obstetrics and Gynecology, Public Hospital, Malatya, Turkey.

出版信息

Med Sci Monit. 2018 Jan 4;24:58-66. doi: 10.12659/msm.906652.

DOI:10.12659/msm.906652
PMID:29298972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5764117/
Abstract

BACKGROUND In the present study we retrospectively evaluated the results of outpatients who had an HPV analysis, and present objective evidence for the administration of preventive inoculation in our area. MATERIAL AND METHODS We retrospectively reviewed 532 outpatients who visited a single center between 2012 and 2016 and had an HPV infection analysis. The criteria for inclusion of patients with unhealthy cervix in the study were: erosion, chronic cervicitis, healed lacerations, hypertrophied cervix, and abnormal discharges from the cervix. RESULTS We found that 122 out of 532 patients were infected with HPV, and the rate of multiple infections was 59.0% (72/122). HR-HPV (group 1 carcinogens HPV-16 (18.9%, 23/122), HPV-18 (13.1%, 16/122), HPV- 31 (4.9%, 6/122), HPV-33 (3.3%, 4/122), HPV-35 (7.4.9%/122), HPV-39 (5.7%, 7/122), HPV-45 (5.7%, 7/122), HPV-51 (11.5%, 15/122); Group 3 LR-HPV; HPV-6 (31.1%, 38/122), HPV-11 (26.2%, 32/122), HPV-42 (9.0%, 11/122) and HPV-43 (4.9%, 6/122). In terms of linear-by-linear association test, no significant statistical difference was identified between years. The P value for HPV infection rate on year basis was P>0.05. CONCLUSIONS In this hospital-based retrospective analysis, HPV types were found to be similar to HPV types reported in developed countries. We firmly suggest that patients should be informed about the risk of HPV infection at early ages.

摘要

背景

本研究回顾性分析了在我院门诊就诊并进行 HPV 分析的患者的结果,为该地区预防性接种提供客观依据。

材料和方法

我们回顾性分析了 2012 年至 2016 年期间在单一中心就诊并进行 HPV 感染分析的 532 例门诊患者。将不健康宫颈患者纳入研究的标准为:糜烂、慢性宫颈炎、愈合裂伤、宫颈肥大和宫颈异常分泌物。

结果

我们发现,532 例患者中 122 例 HPV 感染,多重感染率为 59.0%(72/122)。高危型 HPV(HR-HPV)(1 组致癌 HPV-16(18.9%,23/122)、HPV-18(13.1%,16/122)、HPV-31(4.9%,6/122)、HPV-33(3.3%,4/122)、HPV-35(7.4%,6/122)、HPV-39(5.7%,7/122)、HPV-45(5.7%,7/122)、HPV-51(11.5%,15/122);3 组低危型 HPV(LR-HPV)HPV-6(31.1%,38/122)、HPV-11(26.2%,32/122)、HPV-42(9.0%,11/122)和 HPV-43(4.9%,6/122)。线性-by-linear 关联检验显示,各年份 HPV 感染率无显著统计学差异,HPV 感染率的 P 值为 P>0.05。

结论

在本医院回顾性分析中,HPV 类型与发达国家报道的 HPV 类型相似。我们强烈建议患者在年轻时就应了解 HPV 感染的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7c2/5764117/cc2e74d28483/medscimonit-24-58-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7c2/5764117/bf19414d036a/medscimonit-24-58-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7c2/5764117/1384109d8543/medscimonit-24-58-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7c2/5764117/cc2e74d28483/medscimonit-24-58-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7c2/5764117/bf19414d036a/medscimonit-24-58-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7c2/5764117/1384109d8543/medscimonit-24-58-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7c2/5764117/cc2e74d28483/medscimonit-24-58-g003.jpg

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