Malhotra Akshay, Jain Manju, Prakash Hridayesh, Vasquez Karen M, Jain Aklank
Center for Biochemistry and Microbial Sciences, Central University of Punjab, Bathinda, Punjab, India.
Laboratory of Translational Medicine, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India.
Oncotarget. 2017 Nov 8;8(66):110671-110684. doi: 10.18632/oncotarget.22577. eCollection 2017 Dec 15.
Chemoresistance is one of the major hurdles in the treatment of breast cancer, which limits the effect of both targeted and conventional therapies in clinical settings. Therefore, understanding the mechanisms underpinning resistance is paramount for developing strategies to circumvent resistance in breast cancer patients. Several published reports have indicated that lncRNAs play a dynamic role in the regulation of both intrinsic and acquired chemoresistance through a variety of mechanisms that endow cells with a drug-resistant phenotype. Although a number of lncRNAs have been implicated in chemoresistance of breast cancer, their mechanistic roles have not been systematically reviewed. Thus, here we present a detailed review on the latest research findings and discoveries on the mechanisms of acquisition of chemoresistance in breast cancer related to lncRNAs, and how lncRNAs take part in various cancer signalling pathways involved in breast cancer cells. Knowledge obtained from this review could assist in the development of new strategies to avoid or reverse drug resistance in breast cancer chemotherapy.
化疗耐药是乳腺癌治疗中的主要障碍之一，它限制了靶向治疗和传统治疗在临床环境中的效果。因此，了解耐药的潜在机制对于制定规避乳腺癌患者耐药的策略至关重要。一些已发表的报告表明，长链非编码RNA（lncRNAs）通过多种赋予细胞耐药表型的机制，在内在和获得性化疗耐药的调控中发挥动态作用。尽管许多lncRNAs与乳腺癌的化疗耐药有关，但其作用机制尚未得到系统综述。因此，在此我们对与lncRNAs相关的乳腺癌化疗耐药获得机制的最新研究发现进行详细综述，以及lncRNAs如何参与乳腺癌细胞涉及的各种癌症信号通路。从本综述中获得的知识有助于开发新策略，以避免或逆转乳腺癌化疗中的耐药性。
