伊朗库姆产OXA-143型β-内酰胺酶的首次报告。
First report of OXA-143-lactamase producing in Qom, Iran.
作者信息
Sarikhani Zohreh, Nazari Razieh, Nateghi Rostami Mahmoud
机构信息
Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Basic Med Sci. 2017 Nov;20(11):1282-1286. doi: 10.22038/IJBMS.2017.9490.
OBJECTIVES
Antibiotic resistance in and outbreaks caused by this organism have been reported from several areas of the world. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian isolates from Qom of Iran.
MATERIALS AND METHODS
For this study, 108 non-duplicate isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran. The antimicrobial susceptibility of isolates was tested by standard disk diffusion and prevalence of OXA genes was investigated by PCR method.
RESULTS
Among 97 carbapenem non-susceptible isolates of , 90.72% (88 isolates) isolates showed extensive drug resistance to multiple antibiotics. Among carbapenem resistant isolates, 100% carried , 82.47% carried , 55.67% carried , 22.68% carried and 14.43% had resistance genes.
CONCLUSION
This study demonstrated high genetic diversity of OXA genes among isolates of in Qom, Iran.
目的
世界多个地区已报道了该微生物的抗生素耐药性及由其引起的暴发情况。本研究旨在确定伊朗库姆地区伊朗分离株的抗生素敏感性谱以及OXA型β-内酰胺酶的分布情况。
材料与方法
本研究中，从伊朗中部库姆的四家教学医院的临床标本中获取了108株非重复分离株。采用标准纸片扩散法检测分离株的抗菌敏感性，并通过PCR方法研究OXA基因的流行情况。
结果
在97株对碳青霉烯不敏感的分离株中，90.72%（88株）的分离株对多种抗生素表现出广泛耐药。在碳青霉烯耐药分离株中，100%携带 ，82.47%携带 ，55.67%携带 ，22.68%携带 ，14.43%具有 耐药基因。
结论
本研究表明伊朗库姆地区分离株中OXA基因具有高度的遗传多样性。
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