Eindhoven University of Technology, WTB/MaTe and ICMS , Eindhoven, The Netherlands.
Biomacromolecules. 2018 Feb 12;19(2):386-391. doi: 10.1021/acs.biomac.7b01479. Epub 2018 Jan 16.
Embolization is a nonsurgical, minimally invasive procedure that deliberately blocks a blood vessel. Although several embolic particles have been commercialized, their much wider applications have been hampered owing mainly to particle size variation and uncontrollable degradation kinetics. Herein we introduce a microfluidic approach to fabricate highly monodisperse gelatin microparticles (GMPs) with a microshell structure. For this purpose, we fabricate uniform gelatin emulsion precursors using a microfluidic technique and consecutively cross-link them by inbound diffusion of glutaraldehyde from the oil continuous phase to the suspending gelatin precursor droplets. A model micromechanic study, carried out in an artificial blood vessel, demonstrates that the extraordinary degradation kinetics of the GMPs, which stems from the microshell structure, enables controlled rupturing while exhibiting drug release under temporary chemoembolic conditions.
栓塞是一种非手术的微创治疗方法，它故意阻塞血管。尽管已经有几种栓塞颗粒商业化，但由于颗粒尺寸变化和不可控的降解动力学，它们的应用范围受到了很大限制。在此，我们介绍了一种微流控方法，用于制造具有微壳结构的高度单分散明胶微球（GMP）。为此，我们使用微流控技术制造均匀的明胶乳液前体，并通过戊二醛从油连续相向内扩散到悬浮的明胶前体液滴，连续交联它们。在人工血管中进行的模型微力学研究表明，GMP 的特殊降解动力学源于微壳结构，使其能够在临时化学栓塞条件下控制破裂并释放药物。
