a Beijing Laboratory of Biomedical Materials , College of Materials Science and Engineering, Beijing University of Chemical Technology , Beijing , PR China.
J Drug Target. 2018 Sep;26(8):720-729. doi: 10.1080/1061186X.2018.1424859. Epub 2018 Jan 16.
Microneedles (MNs) system for transdermal drug delivery has the potential to improve therapeutic efficacy, proving an approach that is more convenient and acceptable than traditional medication systems. This study systematically researched dissolving polymer MNs fabricated from various common FDA-approved biocompatible materials, including gelatine, chitosan, hyaluronic acid (HA) and polyvinyl alcohol (PVA). Upon application of MN patches to the porcine cadaver skin, the MNs effectively perforated the skin and delivered drugs to subcutaneous tissue on contact with the interstitial fluid. Both the in vitro and in vivo drug release tests showed the similar trends but different release rates among the prepared MNs. Interestingly, the drug-release kinetics of PVA MNs were able to be altered by changing the molecular weight. To evaluate the feasibility using the proposed MNs for treating diabetes, an in vivo insulin absorption study in diabetic mice was performed. The results showed different insulin release properties of MNs fabricated from various kinds of polymer, leading to different decrease in blood glucose levels. We made a systematic and comprehensive study of some drug-loaded polymer MNs, and anticipated that dissolving polymer MNs have potential to improve therapeutic efficacy through controlled drug release.
微针（MNs）系统用于经皮药物递送，具有提高治疗效果的潜力，证明了这种方法比传统的药物系统更方便、更易于接受。本研究系统地研究了由各种常见的 FDA 批准的生物相容性材料制成的溶解聚合物 MNs，包括明胶、壳聚糖、透明质酸（HA）和聚乙烯醇（PVA）。将 MN 贴片应用于猪尸体皮肤后，MNs 有效地刺穿皮肤，并在与间质液接触时将药物输送到皮下组织。体外和体内药物释放试验表明，在制备的 MNs 之间存在相似的趋势，但释放速率不同。有趣的是，通过改变分子量，可以改变 PVA MNs 的药物释放动力学。为了评估使用所提出的 MNs 治疗糖尿病的可行性，在糖尿病小鼠中进行了体内胰岛素吸收研究。结果表明，由各种聚合物制成的 MNs 具有不同的胰岛素释放特性，导致血糖水平降低程度不同。我们对一些载药聚合物 MNs 进行了系统和全面的研究，预计溶解聚合物 MNs 有可能通过控制药物释放来提高治疗效果。
