School of Public Health, Guangxi Medical University, Nanning, 530021, People's Republic of China.
Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, People's Republic of China.
Lipids Health Dis. 2018 Jan 4;17(1):2. doi: 10.1186/s12944-017-0644-x.
Leptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR). We conducted this study to explore the association of polymorphisms in LEPR with type 2 diabetes mellitus (T2DM) and its related metabolic traits.
We performed a case-control study to investigate the association of polymorphisms in LEPR with T2DM and related metabolic traits in a Chinese population, with a total of 922 T2DM patients and 1031 nondiabetic subjects. Polymorphisms were genotyped using MassARRAY assay.
The G allele of rs1327118 was associated with a decreased risk of T2DM in men (P = 0.044, odds ratio = 0.707, 95% confidence interval = 0.504-0.991) and the G allele of rs3806318 was associated with increased systolic blood pressure (SBP) in men with T2DM. Besides, the women patients carrying the G allele of rs1327118 showed increased SBP and diastolic blood pressure (DBP) levels, but decreased high density lipoprotein cholesterol (HDL-C) level.
Our results suggest that rs1327118 may be associated with SBP, DBP and HDL-C levels in women with T2DM, and rs3806318 may be associated with T2DM and SBP level in men with T2DM. Further studies with larger sample size or functional experiments focused on exact mechanism are required to verify our observations.
瘦素通过激活瘦素受体（LEPR）作为炎症和能量稳态的介质。我们进行这项研究是为了探索 LEPR 多态性与 2 型糖尿病（T2DM）及其相关代谢特征的关系。
我们进行了一项病例对照研究，以探讨 LEPR 多态性与中国人群 T2DM 及其相关代谢特征的关系，共纳入 922 例 T2DM 患者和 1031 例非糖尿病对照。采用 MassARRAY assay 检测多态性。
rs1327118 的 G 等位基因与男性 T2DM 的发病风险降低相关（P=0.044，比值比=0.707，95%置信区间=0.504-0.991），rs3806318 的 G 等位基因与男性 T2DM 患者的收缩压（SBP）升高相关。此外，携带 rs1327118 G 等位基因的女性患者 SBP 和舒张压（DBP）水平升高，但高密度脂蛋白胆固醇（HDL-C）水平降低。
我们的结果表明，rs1327118 可能与女性 T2DM 患者的 SBP、DBP 和 HDL-C 水平有关，rs3806318 可能与男性 T2DM 患者的 T2DM 和 SBP 水平有关。需要更大样本量或针对确切机制的功能实验进一步研究来验证我们的观察结果。
