Chemical composition and antifungal effect of hydroalcoholic extract of against species.

BACKGROUND AND PURPOSE

Treatment of life-threatening fungal infections caused by species has become a major problem. spp. are the most important causative agents of candidiasis. is a medicinal plant that has been traditionally used to treat infections. In the present study, we aimed to determine the chemical compounds and antimicrobial activity of hydroalcoholic extract of against different species of

MATERIALS AND METHODS

Phytochemical analysis was performed to identify the possible bioactive components of this extract by using gas chromatography and mass spectroscopy (GC-MS). The hydroalcoholic extract of were collected. Different concentrations of (50, 25, 12.5, and 6.25 mg/ml) were used to evaluate its antifungal activity against species ( and ) using disk diffusion assay.

RESULTS

The GC-MS analysis revealed the presence of 40 different phytoconstituents with peak area; the major compounds were tetracosane, hexadecanoic acid, 1-eicosanol, 1,2-dihydro-pyrido[3,2,1-kl]phenothiazin-3-one, 2-hexadecen-1-ol, and 3,7,11,15-tetramethyl. Hydroalcoholic extract showed strong antimicrobial activity (inhibition zone ⩾ 20 mm), moderate antimicrobial activity (inhibition zone < 12-20 mm), and no inhibition (zone < 12 mm). In addition, the hydroalcoholic extract exhibited the highest antimicrobial properties against strains.

CONCLUSION

extract had a considerable inhibitory effect against various species, but its highest inhibitory effect was against Further investigations are required to detect the performance of this plant in the treatment of infection.